Titlebook: Antidepressants; Brian E. Leonard Book 2001 Springer Basel AG 2001 clinical research.depression.immune system.pharmacology.psychopharmacol

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Long-term course, comorbidity and long-term outcome in depressive disorders on results from controlled randomised trials in which new antidepressants have been tested. However, there are many differences between patients included in clinical trials and patients in clinical practice [.]. In clinical practice psychiatric comorbidity is common, while those patients often are

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Do antidepressants really take several weeks to show effect?s and placebo do not normally reach statistical significance until the 3rd or 4th week of treatment. This statistical “response lag” has finally led to the “delayed onset of action” hypothesis, although response-to-treatment and onset-of-action represent two principally different concepts that relat

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