Titlebook: Anticoagulation Therapy; Joe F. Lau,Geoffrey D. Barnes,Michael B. Streiff Book 2018 Springer International Publishing AG, part of Springer

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https://doi.org/10.1007/978-3-662-62034-2lex. However, delayed diagnosis and inadequate or inappropriate treatment can lead to life- and limb-threatening outcomes. This chapter will describe the syndrome of HIT (and HITT—heparin-induced thrombocytopenia with thrombosis) as it is now known, including its history, pathophysiology, diagnostic

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Introduction,uman anatomy in health and disease led to greater understanding of the pathophysiology of thrombotic disease and the first treatments for it. Modern approaches to treatment of arterial and venous thromboembolism emerged in the late 19th and 20th centuries with the identification of acetylsalicylic a

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Warfaringh very effective for prevention and treatment of venous and arterial thromboembolism, warfarin has a narrow therapeutic index, many drug, disease, and dietary interactions, and requires frequent monitoring and dose adjustments (Ageno et al., Chest 141(2 Suppl):e44S–88S, 2012; Holbrook et al., Chest

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Unfractionated Heparin and Low-Molecular-Weight Heparindications, including the treatment of venous thromboembolism, thromboprophylaxis, and acute coronary syndromes. In this chapter, we review the evidence-based recommendations and pharmacology of both UFH and LMWH with a detailed description of their mechanisms of action, pharmacokinetics, and pharmac

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Parenteral Anticoagulants: Direct Thrombin Inhibitors and Pentasaccharideses. These include a non-specific mechanism of action, high degree of non-specific binding to plasma components, unpredictable pharmacokinetics and pharmacodynamics, considerable inter- and intra-patient variability, a narrow therapeutic index, need for routine monitoring, and the potential for adver

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Direct Oral Anticoagulantsan—have been approved for prevention of stroke in non-valvular atrial fibrillation and treatment of venous thromboembolism (VTE). All except edoxaban also are approved to prevent VTE in hip and knee replacement surgery. In the atrial fibrillation trials, the DOACs were non-inferior to warfarin dose-

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Anticoagulation Reversal such therapy have to be outweighed against the risks of major bleeding complications. Such risk varies according to age and has been reported to be as low as 2–3% per year in adults to as high as 6–8% per year in the elderly. Reversal strategies are important both for the treatment of such major he

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Transitioning Between Anticoagulantsrsible, does not require monitoring, and can be used in patients with end-stage renal disease and moderate-severe liver dysfunction—is not available to date. Currently, the differences in the pharmacokinetic and pharmacodynamic properties of each agent allow for a unique, individualized anticoagulat

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The Anticoagulation Clinicfe and effective anticoagulation relies upon an organized system of care delivery, close collaboration between healthcare teams, effective communication with patients, and anticoagulation management performed by healthcare professionals with specialized training. The anticoagulation management servi

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Perioperative Management of Anticoagulantstients scheduled for surgery is challenging, as the interruption of therapy may increase the risk of thromboembolism, and continuation may predispose patients to increased peri- and intraoperative bleeding risks. It is therefore crucial to conduct an individualized and thorough periprocedural assess