Titlebook: Anticancer Drug Discovery and Development: Natural Products and New Molecular Models; Proceedings of the S Frederick A. Valeriote,Thomas H.

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The Therapeutic Potential of Novel Pure Antiestrogens,n “Nolvadex”* [tamoxifen: ICI 46,474]. Effective palliation of both advanced and primary breast cancer is achieved without significant side effects by daily oral administration of “Nolvadex” (1,2). In view of this experience, it is reasonable to question whether there is either a clinical need, or p

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Bropirimine, a Small-Molecule Biological Response Modifier and an Effective Antitumor Agent, agent is currently under Phase II clinical trial for its antitumor efficacy. In 1976, a 6-alkylpyrimidinone [2-amino-5-bromo-6-methyl-4(3H)-pyrimidinone, ABMP] was reported to induce circulating interferon (IFN) in animals upon oral (po) or intraperitoneal (ip) administration (3,4). Further researc

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Anticancer Drug Discovery and Development: Natural Products and New Molecular ModelsProceedings of the S

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or bringing together the principal groups involved in bothdiscovering and developing new approaches to the treatment of cancer.This Second Symposium emphasized the types of materials beingdiscovered and their therapeutic activity. This is especially evidentin the natural product discovery programs,