Titlebook: Anticancer Drug Development Guide; Preclinical Screenin Beverly A. Teicher (Vice President and Director of Book 2004 Springer Science+Busin

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Lino Schmid,Thomas Holleczek,Gerhard Tr?ster important role in drug evaluation, but with the development of a large number of cytotoxic drugs, animal models are too costly and the delay is too long for these models to be used for large-scale screening.

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https://doi.org/10.1007/978-3-540-34049-2, experimental agents have limited antiproliferative data against a broad spectrum of human cancers, and these agents usually are then tested in the NCI’ s in vitro anticancer drug screen. Data from the screen permits the identification of agents that exhibit differential activity among multiple tum

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https://doi.org/10.1007/978-3-540-34049-2novative therapies. Most of this work has been performed on inbred rodent models and laboratory-derived canine populations. Working with inbred populations in controlled, artificial laboratory environments raises some degree of concern over the applicability of information as it relates to naturally