Titlebook: Antibody-Drug Conjugates and Cellular Metabolic Dynamics; Shuqing Chen,Jinbiao Zhan Book 2023 The Editor(s) (if applicable) and The Author

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https://doi.org/10.1007/978-3-662-48505-7f a determined number of drugs to a determined site of the antibody, ensuring consistency between batches, minimizing the heterogeneity of the ADCs and making its properties more predictable. We focused on the commonly used site-directed conjugation strategies including engineered cysteine conjugati

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https://doi.org/10.1007/978-981-19-5638-6Antibody-drug conjugates; Cellular Metabolic Dynamics; Cellular internalization; Intracellular traffick

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Application of Antibody Fragments in ADCs,rized antibodies not only retain the specificity and affinity of total antibody, but also have faster tissue penetration and relatively short half-life, which can effectively avoid off-target toxicity. Therefore, the miniaturization of ADC is an effective method to solve the limitation of traditional ADC drugs.