Titlebook: Antibiotic Resistance; Anthony R.M. Coates Book 2012 The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-

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Einige weitere statisch bestimmte Systeme,get for antimicrobial therapy and the development of new antibacterials to address the efflux problem..Tigecycline is an example of how old antibiotics, in this case tetracyclines, which have become substrates for efflux pumps, can be extensively modified to restore antimicrobial activity and clinical efficacy.

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Efflux: How Bacteria Use Pumps to Control Their Microenvironment,get for antimicrobial therapy and the development of new antibacterials to address the efflux problem..Tigecycline is an example of how old antibiotics, in this case tetracyclines, which have become substrates for efflux pumps, can be extensively modified to restore antimicrobial activity and clinical efficacy.

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https://doi.org/10.1007/978-3-7091-3582-2ain of bacteria, and this may also be combined with an increase in virulence, both of which are leading to a significant increase in morbidity and mortality in patients. Against this background, the absolute number of new antibiotics licensed has declined especially for Gram-negative multidrug-resis

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