Titlebook: Anti-Inflammatory Drugs in Asthma; Anthony P. Sampson,Martin K. Church Book 1999 Springer Basel AG 1999 Atmen.allergy.asthma.cytokine.rese

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Anti-Leukotriene Therapy for Asthma,s), and characterised by a range of abnormalities on various levels. Early definitions of asthma stressed the aspects of variable lung function, reversible spontaneously or with treatment, but more recent definitions also place emphasis on the underlying airway inflammation that is thought to promot

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Immunomodulators,ating and orchestrating this inflammatory response. Many types of cells are involved, the airway epithelium is shed; eosinophils, T lymphocytes, polymorphonuclear cells, mast cells, and macrophages are present in an activated state and release proinflammatory mediators, cytokines and growth factors.

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Anti-IgE Agents,ulate allergen-specific B cells to produce IgE molecules via the release of IL-4/IL-13. The receptors for IgE are found on a multitude of different cells and two different types have been identified: the high-affinity receptor (FcεRI) on mast cells, basophils, and antigen-presenting cells, and the l

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Mast Cell Proteases as New Targets for Therapeutic Intervention in Asthma,roughout the body, but are particularly prevalent in tissues which form an interface with the external environment. In the lower airways mast cells are numerous in the bronchial mucosa [2], submucosa and alveolar walls [3], and are even found free in the lumen [4]. The activation of mast cells by al