Titlebook: Annual Update in Intensive Care and Emergency Medicine 2016; Jean-Louis Vincent Book 2016 Springer International Publishing Switzerland 20

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Reducing Antibiotic Use in the ICU: A Time-Based Approach to Rational Antimicrobial Useection, community-acquired, healthcare-associated and hospital-acquired, timely administration of antibiotic therapy active against the causal pathogen is one of the main determinants of a favorable patient outcome. On the other hand, it is an undeniable fact that antibiotics need to be used judicio

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Immunomodulation: The Future for Sepsis?f 40%[1]. In addition to infection control, which associates early and appropriate antimicrobial agents and sometimes surgery, treatment has long been limited to the supportive care of organ dysfunction. The complex host immune response to sepsis is progressively becoming understood [2]. Numerous li

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Norepinephrine in Septic Shock: Five Reasons to Initiate it Earlylemia, peripheral vascular dysfunction resulting in hypotension and abnormalities in the local/ regional distribution of blood flow, cardiac failure and cell dysfunction. Importantly, the hemodynamic profile differs from patient to patient. In some septic patients, hypovolemia is predominant. In oth