Titlebook: Animals in Scientific Research: An Effective Substitute for Man?; Proceedings of a Sym Paul Turner (Professor) Conference proceedings 1983L

antipsychotic

The design and use of , testsin this category have been made (e.g. Miller, 1978). In addition, several hundred new chemicals are being introduced each year which require some form of toxicological investigation. On the other hand there are mounting economic and moral pressures to change the testing methods that are currently employed.

GEM

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烤架

The use of short term tests to detect the carcinogenic and mutagenic potential of environmental chemir contents to produce new forms or mutants. This process of mutation occurs spontaneously but may be dramatically increased by a variety of chemical and physical agents. The products produced by such mutant genes may lead to a range of inherited diseases and have also been implicated in the product

BARK

The design and use of , testschemicals for which inadequate toxicological information exists and to which man is significantly exposed. Estimates that 30,000–50,000 chemicals are in this category have been made (e.g. Miller, 1978). In addition, several hundred new chemicals are being introduced each year which require some form

Abduct

挑剔為人

A review of the value of isolated hepatocyte systems in xenobiotic metabolism and toxicity studiestoxic damage elicited by drugs and other foreign chemicals (here collectively designated as ‘xenobiotics’). This, undoubtedly, arises for a number of reasons including (a) the fact that the liver is the first major organ to receive the xenobiotic after absorption from a per oral dose, and (b) the fa

Lacerate

Isolated human cellular models in clinical pharmacological studies many groups protesting against experimental use of animals. Animal experiments are entirely justified on many occasions, particularly so when the animal species under study will be the chief beneficiaries, for example, in tests of new vetinary products. Studies of drugs and other chemicals in man a

政府

systems in the study of osteoarthritis in severely advanced stages, the underlying subchondral bone is exposed (Lee et al., 1974; Howell et al., 1976; Peyron, 1979). It is common in domestic animals, and in man the highest incidence is in late middle age. Osteoarthritis is diagnosed only at relatively advanced stages of the disease and

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