Titlebook: Animal Models of Obesity; Michael F. W. Festing Book 1979 The Medical Research Council 1979 model.obesity.research

Dri727

Immunity in genetically obese rodents,merican work on the diabetic mouse (C57BL/KsJ-.). The terms ‘obese mouse’ and ‘diabetic mouse’ will be reserved specifically for these mutants. We shall attempt to show how obese rodents can be used as models to analyse the relationship between obesity, diabetes and immunity (see figure 13.1).

Parallel

Comparison of genetic models of obesity in animals with obesity in man,consequence of the obese state—factors which the species are likely to share—and the features primarily responsible for the development of obesity in the different species. The problem in man is more complex than in the genetically obese rodents, since social factors play a much more important part.

Feckless

CONE

NEEDY

Normal variation in body fat and its inheritance,elatively lower maintenance cost. The causation of differences among strains in their ability to partition energy between fat and lean tissues at the same stage of development is less well understood but such differences can be generated by different types of selection for growth rate.

Temporal-Lobe

Violations of the Classical Assumptionse present state of knowledge to say which is the most relevant model of human obesity, it seems better to work with a broad selection of models if the aetiology of obesity and its associated metabolic changes are to be understood.

Nibble

Non-genetic models of obesity,e present state of knowledge to say which is the most relevant model of human obesity, it seems better to work with a broad selection of models if the aetiology of obesity and its associated metabolic changes are to be understood.

NOVA

The inheritance of obesity in animal models of obesity,enic models of obesity usually lie nearer the threshold of normality than the mutants, and are thus more likely to be curable by environmental manipulation. Similarly, fat but not obese ‘normal’ strains may easily be made obese by dietary and other environmental manipulation..Comparative studies of

OREX

CRUC