Titlebook: Animal Models of Epilepsy; Methods and Innovati Scott C. Baraban Book 2009 The Editor(s) (if applicable) and The Author(s), under exclusive

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The Nematode, ,, as an Emerging Model for Investigating Epilepsy,aracterizing the underlying defects associated with epilepsy via mammalian systems are not only laborious and time consuming but also costly. Because epilepsy represents a significant disease burden worldwide .1., there is a serious need to accelerate research by considering non-traditional approach

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Modeling Tuberous Sclerosis Complex: Brain Development and Hyperexcitability,many neurological aspects of TSC. In this chapter I will review the clinical manifestations of TSC, molecular roles of the TSC genes, and current animal models of TSC. These and future models should facilitate the development of new and exciting discoveries that will have a meaningful impact on live

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BK Potassium Channel Mutations Affecting Neuronal Function and Epilepsy,list of mutations causing epilepsy in humans and mice. BK channels have the specialized role of sharpening action potentials in many excitatory neurons. Surprisingly, functional analysis in heterologous expression systems indicates that some of these mutations are gain of function. This paradoxical

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