Titlebook: Anhedonia: Preclinical, Translational, and Clinical Integration; Diego A. Pizzagalli Book 2022 The Editor(s) (if applicable) and The Autho

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Anhedonia: Preclinical, Translational, and Clinical Integration

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Clinical and Preclinical Assessments of Anhedonia in Psychiatric Disordersd anticipation, motivation, effort expenditure, reward valuation, expectation, pleasure, satiation, and learning. In order to further elucidate the impact of anhedonia on treatment outcomes, quality of life, as well as brain function, validated tools to probe the various facets of anhedonia are nece

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Developmental Trajectories of Anhedonia in Preclinical Modelse development of anhedonia in the context of early-life adversity, and the power of preclinical models to tease out the diverse molecular, epigenetic, and network mechanisms that are responsible for anhedonia-like behaviors..Specifically, we first discuss the term anhedonia, reviewing the conceptual

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Understanding Anhedonia from a Genomic Perspectiveopathology. Supportive of long-held theory that anhedonia represents a genetically influenced vulnerability marker for depression, evidence from twin studies suggests that it is moderately-largely heritable. However, the genomic sources of this heritability are just beginning to be understood. In th

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Environmental Contributions to Anhedoniautionary accounts of depression suggest that decreased motivation to pursue reward may be an adaptive strategy in the face of social stress, in particular, as it may serve to defuse interpersonal conflict. Through a review of rodent models and research with humans, we show that exposure to stress, p

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