Titlebook: Anhedonia: Preclinical, Translational, and Clinical Integration; Diego A. Pizzagalli Book 2022 The Editor(s) (if applicable) and The Autho

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Anhedonia in Neurodegenerative Diseasesugh the two syndromes can be dissociated. Intriguingly, drugs that improve apathy can also lead to amelioration of anhedonia in some cases. Overlaps between the two syndromes may also exist across other neurodegenerative conditions, including Frontotemporal Dementia in which imaging has revealed atr

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Pleasure, Reward Value, Prediction Error and Anhedoniapleasure in depression and schizophrenia. There is some evidence that learning about reward and reward prediction error signals are impaired in depression and schizophrenia, but the literature is inconsistent. The strongest evidence is for impairments in the representation of reward value and how th

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M. Mucciarelli,D. Albarello,M. Stucchisks that probe responses to rewarding stimuli have been useful to fill this gap and to delineate the specific brain processes underlying facets of anhedonia. Although there have been translational challenges in the assessments of anhedonia and reward deficits from preclinical to clinical (and vice v

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Beno?t Lebrun,D. Hatzfeld,P. Y. Bardfollow with an overview of the state of current knowledge of brain circuits, nodes, and projections that execute distinct aspects of hedonic-like behaviors, as well as neurotransmitters, modulators, and receptors involved in the generation of anhedonia-like behaviors. Finally, we discuss the special

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Seismicity of the Pannonian Basinh requirements and frameworks that prioritize sample size over precise phenotyping. This has resulted in few and underpowered studies of anhedonia-related constructs that have largely failed to reliably identify individual variants. Nonetheless, the polygenic architecture of anhedonia-related constr

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