Titlebook: Angiotensin II Receptor Blockade Physiological and Clinical Implications; Naranjan S. Dhalla (Distinguished Professor and Di Book 1998 Spr

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The Place of Angiotensin II Antagonists in Relation to the Canadian Hypertension Society Guidelineso be effective than the earlier pharmacological approach of inhibiting the enzyme (ACE inhibitor) responsible for converting Ang I to Ang II. Furthermore, it is expected that the approach will avoid problems associated with pathways that bypass ACE, e.g., tissue chymase..Two major subtypes of recept

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Cough Induced by Pharmacological ModulatiOn of the Renin-Angiotensin-Aldosterone System. Angiotensing a different class of antihypertensive agents for the offending ACE inhibitors. Losartan potassium represents a new class of antihypertensive agents with a different mechanism of action: it directly blocks the effects of angiotensin (Ang) II at the receptor level, without affecting kininase II-rela

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Angiotensin Receptor Antagonists and Cardiovascular Remodeling in the vascular and cardiac remodeling observed in response to chronic or acute hypertension. Two major Ang II receptor subtypes, AT. and AT., have been described, and their roles in vivo and in vitro have now been investigated using nonpeptidic antagonists, losartan and PD123319, which block AT. a

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Functional Analysis of Tissue Renin-Angiotensin System Using “Gain and Loss of Function” Approaches:vo studies are limited. Recent progress in in vivo gene transfer technologies have provided us with the opportunity to study cellular responses to the manipulation of the individual components (i.e., by overexpression or inhibition). Currently, many researchers have developed many in vivo gene trans

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Role of Cytokines in Septic Cardiomyopathyf human septic myocardial depression in intensive care patients was only unequivocally proved in the 1980s by the group of Parrillo, utilizing a nuclear imaging technique. Septic cardiomyopathy is frequently masked by a seemingly normal cardiac output. However, relative to the lowered systemic vascu