Titlebook: Angiogenesis and Vascularisation; Cellular and Molecul Józef Dulak,Alicja Józkowicz,Agnieszka ?oboda Book 2013 Springer-Verlag Wien 2013 en

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https://doi.org/10.1007/978-3-319-56330-5on and invasion of capillary sprouts into its surrounding matrix. (Membrane-type) matrix metalloproteases [(MT-)MMPs], ADAM(TS) metalloproteases, serine proteases, their inhibitors, and occasionally cysteine proteases are important players in pericellular proteolysis. The specific location and short

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Pediatric Airway and Esophagologyproteins that fold into a conserved structure and employ a unique suicide substrate-like inhibitory mechanism. Most of them act as classical protease inhibitors, but there are also serpins that inhibit other types of proteinases, e.g., caspases, or have different, noninhibitory functions, e.g., horm

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Pediatric Otology and Cochlear Implantsre the ETS factors, a large family of which at least 19 members are expressed in human endothelial cells at some point throughout development. Through interaction with other TF families and co-regulators, ETS factors control most aspects of endothelial biology, from early differentiation in the embr

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Anthony Del Signore,Todd Spock,Zara M. Patelbiology and pathobiology of the cell. These span transcription factors, cytokines, growth factors, enzymes, secreted factors, cytoskeletal proteins, transporters and anti-apoptotic proteins that are attractive targets for the control of pathologic angiogenesis. This chapter focuses on immediate-earl

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Anni Wong,Anthony Del Signore,Fred Y. Linmostly through transcriptional regulation of genes which contain a core consensus sequence called hypoxia response element (HRE) via hypoxia inducible factors (HIFs) action. The discovery of HIFs hydroxylases as a family of dioxygenases that regulate HIFs dependently on the oxygen availability have

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Jeffrey Cheng M.D.,Eric Berg M.D.n of gene expression in a temporal-spatial manner. microRNAs (miRs) are 18–24 nucleotide-containing endogenous RNAs that exert substantial gene regulatory effects via a posttranscriptional mechanism. Recent advance in basic research revealed that miRs exert potent angiogenic control via direct targe

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Anthony G. Del Signore M.D.,Fred Y. Lin M.D.rted. Amongst Nrf2 target genes, heme oxygenase-1 (HO-1) is responsible for at least a part of such protective effects by playing strong antioxidant and anti-inflammatory roles in the vascular system. Nonetheless, the area of Nrf2/HO-1 functioning could be extended to the control of vessel growth. A

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Jeffrey Cheng M.D.,Eric Berg M.D.iogenesis produced by endothelial cells, and then VASH2 as a homologue of VASH1. We further explored that VASH1 is expressed in endothelial cells to terminate angiogenesis, whereas VASH2 is expressed in non-endothelial cells in the sprouting front to promote angiogenesis. This chapter will focus on

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