Titlebook: Angiogenesis; From the Molecular t Michael E. Maragoudakis Book 2000 The Editor(s) (if applicable) and The Author(s), under exclusive licen

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Signal Transduction and Transcriptional Regulation of Angiogenesise, proliferate and form new vessels. However, the molecular mechanism of these events is not fully characterized yet. We are studying the signal transduction and transcriptional regulation of angiogenesis. We investigated the properties of two VEGF receptors, Flt-1 and KDR, by using two newly develo

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Sensitivity of Different Vascular Beds in the Eye to Neovascularization and Blood-Retinal Barrier Brprematurity. An understanding of the angiogenic factors promoting this abnormal vascular growth is necessary to devise a therapeutic approach to inhibit NV. One factor known to promote NV is vascular endothelial growth factor (VEGF), which can also induce a breakdown of the blood-retinal barrier (BR

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Revascularization of Ischemic Tissues With Sikvav and Neuropeptide Y (Npy)ing and ischemia. We have recently examined .and .the ability of two potent angiogenic compounds, SIKVAV (a peptide derived from the alpha chain of laminin-1) and Neuropeptide Y (NPY) to revascularize ischemic tissue. These compounds were tested in an ex vivo capillary sprouting angiogenesis assay t

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Cellular Effects and Signalling Pathways Activated by the Anti-Coagulant Factor, Protein S, in Vascuy endothelial cells and megakaryocytes in culture. In previous studies we have shown that protein S acts as a mitogen for cultured human vascular smooth muscle cells. The synthesis and secretion of protein S by endothelial cells suggests that in addition to its role in the coagulation cascade, prote

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