Titlebook: Amorphous Solid Dispersions; Theory and Practice Navnit Shah,Harpreet Sandhu,A. Waseem Malick Book 2014 Controlled Release Society 2014 amo

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MBP Technology: Composition and Design Considerations many APIs, some compounds commonly referred to as “brickdust” were not readily amenable to these techniques either due to their high melting points and thermal instability or due to insufficient solubility in volatile organic solvents. An innovative technology, known as microprecipitated bulk powde

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Downstream Processing Considerationsplications for the four manufacturing technologies described in the previous chapters, namely hot-melt extrusion, spray drying, microprecipitated bulk powder, and mesoporous silica. Emphasis is placed on the selection of the formulation composition, the downstream manufacturing process, as well as t

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Structural Characterization of Amorphous Solid Dispersionsolecular level attributes of ASD are extensively discussed. Furthermore, brief accounts on the use of spectroscopic, microscopic, surface analytical, hyphenated, and some emerging techniques for the assessment of ASD microstructure are summarized.

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2192-6204 the use of non-salt-forming organic acids and amino acids for the stabilization of amorphous systems..Amorphous Solid Dispersions: Theory and Practice .is a valuable reference to pharmaceutical scientists inter978-1-4939-4866-6978-1-4939-1598-9Series ISSN 2192-6204 Series E-ISSN 2192-6212

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https://doi.org/10.1007/978-3-663-04643-1 1960s, the application of solid dispersion concept to solve solubility challenges in real world was limited and this was partly due to the lack of commercially viable processing technologies. However, in the past two decades this area has seen remarkable progress as the science and understanding of

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https://doi.org/10.1007/978-3-662-56818-7tory aspects of these excipients also need to be considered for the development of successful products. In summary, excipients play a significant role in stabilizing amorphous solid dispersions, maximizing bioavailability, and overcoming absorption issues associated with poorly soluble drugs.