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Titlebook: Amorphous Solid Dispersions; Theory and Practice Navnit Shah,Harpreet Sandhu,A. Waseem Malick Book 2014 Controlled Release Society 2014 amo

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發(fā)表于 2025-3-21 16:40:04 | 只看該作者 |倒序?yàn)g覽 |閱讀模式
期刊全稱Amorphous Solid Dispersions
期刊簡稱Theory and Practice
影響因子2023Navnit Shah,Harpreet Sandhu,A. Waseem Malick
視頻videohttp://file.papertrans.cn/155/154734/154734.mp4
發(fā)行地址Provides comprehensive coverage of theoretical and practical aspects of amorphous formulation development.Emphasizes state-of-the-art, cutting-edge technologies in the field.Presents case studies of m
學(xué)科分類Advances in Delivery Science and Technology
圖書封面Titlebook: Amorphous Solid Dispersions; Theory and Practice Navnit Shah,Harpreet Sandhu,A. Waseem Malick Book 2014 Controlled Release Society 2014 amo
影響因子.This volume offers a comprehensive guide on the theory and practice of amorphous solid dispersions (ASD) for handling challenges associated with poorly soluble drugs. In twenty-three inclusive chapters, the book examines thermodynamics and kinetics of the amorphous state and amorphous solid dispersions, ASD technologies, excipients for stabilizing amorphous solid dispersions such as polymers, and ASD manufacturing technologies, including spray drying, hot melt extrusion, fluid bed layering and solvent-controlled micro-precipitation technology (MBP). Each technology is illustrated by specific case studies. In addition, dedicated sections cover analytical tools and technologies for characterization of amorphous solid dispersions, the prediction of long-term stability, and the development of suitable dissolution methods and regulatory aspects. The book also highlights future technologies on the horizon, such as supercritical fluid processing, mesoporous silica, KinetiSol?, and the use of non-salt-forming organic acids and amino acids for the stabilization of amorphous systems..Amorphous Solid Dispersions: Theory and Practice .is a valuable reference to pharmaceutical scientists inter
Pindex Book 2014
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發(fā)表于 2025-3-21 23:51:41 | 只看該作者
Book 2014ly soluble drugs. In twenty-three inclusive chapters, the book examines thermodynamics and kinetics of the amorphous state and amorphous solid dispersions, ASD technologies, excipients for stabilizing amorphous solid dispersions such as polymers, and ASD manufacturing technologies, including spray d
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Allgemeine Konstitutionspathologief continuous manufacturing. Novel applications, such as devolatilization and development using quality by design, allow for the technology to support both drug substance and drug product manufacturing.
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,Das Alter und seine Identit?t, characterization as well as approaches applicable for stability predictions are discussed. Finally, some practical stability programs that are suitable at different stages of pharmaceutical research and development are introduced. The focus of this chapter is on physical stability of ASD with its chemical stability aspect briefly discussed.
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發(fā)表于 2025-3-22 19:03:29 | 只看該作者
Theoretical Considerations in Developing Amorphous Solid Dispersionsto their glass-forming ability and glass stability. In the main parts of this chapter, we review theoretical approaches to determine amorphous drug polymer miscibility and crystalline drug polymer solubility, as a prerequisite to develop amorphous solid dispersions (glass solutions).
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Fundamentals of Amorphous Systems: Thermodynamic Aspectsamics and microscopic models, and their relationships to improved solubility/dissolution and physical stability are considered. In addition, the relationship between neat amorphous forms and glasses, especially as presented in the literature, is reviewed.
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