Titlebook: Aminopeptidases in Biology and Disease; Nigel M. Hooper,Uwe Lendeckel Book 2004 Springer Science+Business Media New York 2004 biology.neur

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Insulin-Regulated Aminopeptidase,ysiological role attributed to IRAP is the involvement of the enzyme in memory processing. AT. ligands, upon binding to the catalytic site of IRAP, enhance spatial learning, facilitate memory retention and retrieval and reverse amnesia. We postulate that the AT. ligands act via either one of these m

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ERAP1 and MHC Class I Antigen Presentation, is the first aminopeptidase found in the ER and appears to be one of the key factors affecting the repertoire of class I bound antigenic peptides on the cell surface. ERAP1 has broad substrate specificity and trims longer peptides to products of either nine or eight residues, which is the length pr

果核

Alanyl-Aminopeptidases in Human T Cells,lvement of APN and ApPS in the pathological immune response is evident, the precise molecular mechanisms remain to be identified. The development of inhibitors specific for APN and ApPS is an attractive field of study and would allow determination of the individual contribution of either enzyme in t

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Prostaglandins

Nematode Aminopeptidases,ases are most probably conserved in animal and plant parasitic nematodes. Nevertheless, given the complexity of parasite life-cycles, parasitic nematode aminopeptidases are likely to have evolved novel biological roles, the best characterised to date being immunomodulation and immunoprotection. Thes

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,über Wahrscheinlichkeit — eine Topologie,-regulated membrane aminopeptidase (IRAP). P-LAP is translocated from the cytosol to the plasma membrane by oxytocin stimulation in vascular endothelial cells and by vasopressin in renal cells, which is similar to the finding that insulin stimulates IRAP translocation in adipocytes. P-LAP has a wide