Titlebook: Alzheimer’s Disease Research; What Has Guided Rese Christian Behl Book 2023 The Editor(s) (if applicable) and The Author(s), under exclusiv

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Ignorance or Conspiracy? Or Just an , that Blocks Alternative Ideas?,l incidents, reported or found in the literature, could prove that innovative ideas that do not conform with the dominating view in the field are neglected, blinded out, and not accordingly funded. All of this happened in the public eye and rather obviously. As a consequence, an increasing number of

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In the Slip Stream of Amyloid: The ,ntually leading to the formation of tau fibrils and NFTs, thereby disturbing microtubular structure and function and impacting neuronal signal and synaptic transmission. In postmortem Alzheimer’s tissue, tangles are addressed as remnants of degenerated neurons..The ., also called ., defines the deve

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,Alzheimer’s Research Gains Momentum and Spreads Out,bodies were developed as a therapy approach..Besides all the findings that?further confirmed a pathogenic role of amyloid beta?in particular, the physiological role of APP and its fragments was also?brought back into the discussion. Because of the almost exclusive focus on APP as the (pathological)

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The , Has to Deliver, Finally, the pillar in the search for a . therapy. Unfortunately, all the clinical trials aiming to interrupt amyloid beta generation, aggregation, deposition, or its clearance from the brain have?largely failed until 2021..In the last decade, a whole series of anti-amyloid antibodies were tested. With each

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Beyond ,, ,, ,, and ,: What Else Does the Genome Tell Us?,k genes can be largely grouped into three biological categories comprising (1) lipid and cholesterol metabolism and homeostasis, (2) endocytosis, vesicle-mediated transport, trafficking, and (3) immune response..One of the most prominent risk genes identified by GWAS was the gene coding for TREM2 (“

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,Driving Forces of Alzheimer’s Research Directions,or newcomers in a research area, it might look more promising to follow the supported and acknowledged mainstream, meaning the dominating view, rather than going down a controversial path. This certainly applies to some developments in the field of Alzheimer’s research in the last three decades, res

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https://doi.org/10.1007/978-3-662-39472-4ature from already about 1500?years ago. Several forms of dementia exist, and it was owed to the German?psychiatrist Emil Kraepelin who in 1910 gave Alois Alzheimer’s clinical and pathological observations the name “Alzheimersche Krankheit,” Alzheimer’s disease.