Titlebook: Alzheimer Disease; Therapeutic Strategi Ezio Giacobini (Chairman of Pharmacology),Robert E Conference proceedings 1994 Springer Science+Bus

旁觀者

Alzheimer Disease -- A Spirochetosis?e of neuroborreliosis caused by . (Burgdorfer et al., 1982; Pachner et al., 1989), and general paresis, tertiary stage of neurosyphilis caused by .. Two cases of concurrent neocortical borreliosis and Alzheimer disease (AD) have been reported (MacDonald and Miranda, 1987; MacDonald, 1988): immunosta

AMBI

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ABOUT

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Apolipoprotein E and Alzheimer’s Disease: Therapeutic Implicationsd with late-onset familial (Strittmatter et al., 1993a) and sporadic (Saunders et al., 1993) AD. Three major protein isoforms of apoE (apoE2, E3 and E4) are the products of three alleles ?2, ?3, ?4 at a single gene locus on the proximal long arm of chromosome 19q13.2 (Mahley, 1988), within the regio

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Apolipoprotein E4 and Cholinergic Dysfunction in Alzheimer’s Diseaseily by the liver, but also at other sites including brain, macrophages and adrenals (Elshourbagy et al., 1985). Furthermore, apoE is unique among apolipoproteins in that it has a special relevance to the central and peripheral nervous systems. It is a key determinant in the cellular recognition and

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朝圣者

Modulating Cholinergic Neurotransmission Through Transgenic Overexpression of Human Cholinesterasestem (Harding, 1992), suggesting that experimental modulation of cholinergic neurotransmission can serve to study the relationship between cholinergic deficits and neuropathology. To this end, we established transgenic models for overexpressing human cholinesterases (ChEs) (Soreq and Zakut, 1993) in

MINT

Structure-Function Relationships in The Binding of Reversible Inhibitors in the Active-Site Gorge ofase agents are used in treatment of various disorders (Taylor, 1990), and have been proposed as therapeutic agents for managing Alzheimer’s disease (AD) (Becker and Giacobini, 1991). The AChE active site contains a catalytic subsite and a so-called `anionic’ subsite, which binds the quaternary group

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