Titlebook: Alzheimer Disease; Therapeutic Strategi Ezio Giacobini (Chairman of Pharmacology),Robert E Conference proceedings 1994 Springer Science+Bus

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Development of Drugs for Alzheimer Therapy: A Decade of Progressre, some comparisons seem both useful and appropriate. In the seven years (1988–1994) since our first volume (Giacobini and Becker, 1988) we have identified approximately 100 compounds proposed for use in Alzheimer disease (AD) therapy. We have found reference to over 300 studies conducted in humans

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Role of Abnormal Phosphorylation of Tau in Neurofibrillary Degeneration: Implications for Alzheimer hologically, Alzheimer disease (AD) is characterized by the presence of two brain lesions, paired helical filaments (PHF) in the neurons and ?-amyloid in the extracellular space. At present, the exact relationship between PHF and ?-amyloid in the pathogenesis of AD is not understood. However, there

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Olfactory Bulb Involvement in AD: An Early Changenaming of the odorant (Serby et al., 1985; Peabody and Tinklenberg, 1985; Warner et al., 1986; Knupfer and Speigel, 1986; Doty et al., 1987). In contrast, detecting the presence of an odorant (i.e. detection) or discriminating that two odorants are different (discrimination) appear to be relatively