Titlebook: Alcohol Related Diseases in Gastroenterology; Helmut Karl Seitz,Burkhard Kommerell Book 1985 Springer-Verlag Berlin Heidelberg 1985 Alkoho

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978-3-642-70050-7Springer-Verlag Berlin Heidelberg 1985

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Pathology of Alcoholic Liver Disease with Special Emphasis on Alcoholic Hepatitis,ake is a factor in a significant percentage of all deaths, roughly 10% in the United States. It is associated with half of all traffic deaths, many involving teenagers. Cirrhosis of the liver, which ranks among the ten leading causes of death, is largely attributable to excessive alcohol consumption (Lieber 1978; Eckardt et al. 1981).

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Effect of Ethanol on Intestinal Morphology, Metabolism, and Function,ght loss is decreased dietary intake, malabsorption of nutrients may also play a significant contributory role. Both the acute and chronic ingestion of ethanol have varied effects on the morphology, metabolism, and function of the intestine. Furthermore, the effects of ethanol on the intestine often vary depending on the nutritional status.

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Guido Cervone,Pasquale FranzeseThe hepatocyte contains three main pathways for ethanol metabolism, each located in a different subcellular compartment: the alcohol dehydrogenase pathway of the cytosol or the soluble fraction of the cell, the microsomal ethanol-oxidizing system located in the endoplasmic reticulum, and catalase located in the peroxisomes (Fig. 1).

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