Titlebook: Alcohol Intoxication and Withdrawal I; Experimental Studies Milton M. Gross Book 1973 The Editor(s) (if applicable) and The Author(s), unde

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Possible Role of Microsomal Changes Induced by Ethanol Intake in the Development of Tolerance and De discussed favor a possible role of microsomal changes induced by ethanol consumption in the development of the metabolic tolerance to ethanol. Similarly, a hypothesis will be presented according to which the microsomal changes may contribute to the development of dependence. Since this theory resul

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Alcohol Oral Self-Administration in Rats: Attempts to Elicit Excessive Intake and Dependenceronic oral self-administration; 3) The development of a withdrawal syndrome (i.e., physical dependence) upon abrupt withdrawal of alcohol following a period of chronic self-administration; and 4) The development of “psychological dependence” on alcohol, as indicated by, for example, the animals self