Titlebook: Aging and Aging-Related Diseases; Mechanisms and Inter Zhao Wang Book 2018 Springer Nature Singapore Pte Ltd. 2018 Aging.Aging-related Dise

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Ovarian Aging and Osteoporosis,he production of cytokines and growth factors from bone marrow and bone cells. This review will summarize current knowledge concerning ovarian aging and postmenopause osteoporosis and also discuss clinical treatment and new ideas of drug development for osteoporosis.

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Pharmaceutical Intervention of Aging,ters, as well as senolytics. All these interventions modulate the determinants and pathways responsible for aging/longevity, such as the kinase target of rapamycin (TOR), AMP-activated protein kinase (AMPK), sirtuins, and insulin-like growth factor (IGF-1) signaling (Fig. 15.1).

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Peter J. Fraser,Peter Masakazu Takahata clinical and research fields. In this chapter, we review recent advances in circRNA functions and mechanisms and discuss their roles in aging and age-related diseases. It will provide insight into the regulatory roles of circRNAs in aging and age-related diseases.

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Peter J. Fraser,Peter Masakazu Takahataovascular systems. Here we provided a general overview of ncRNAs as well as the underlying mechanisms involved in cardiovascular aging. Although the importance of ncRNAs in cardiovascular aging has been reported and commonly acknowledged, further studies are still necessary to elucidate the underlying molecular mechanisms.

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Systems Biology in Aging Research,l decline in biological system, the methods in systems biology could be utilized in aging studies. Here we reviewed recent advances in systems biology in aging research and divide them into two major parts. One is the data resource, which includes omics data from DNA, RNA, proteins, epigenetic chang