Titlebook: Advances in Systems Biology; Igor I. Goryanin,Andrew B. Goryachev Conference proceedings 2012 The Editor(s) (if applicable) and The Author

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Zooming in on Yeast Osmoadaptationincrease in osmolarity of the external medium (osmoadaptation) is a model adaptation process. The first mathematical model of volume changes in . due to osmolarity has been proposed as early as 1983 by Schwartz and Diller (Cryobiology 20(5):542–552). Since then, both experimental and computational m

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Evolution of the Cognitive Proteome: From Static to Dynamic Network Modelst biochemical technologies means that dissecting the synapse proteome’s dynamic complexity is fast becoming a reality. Here we look at these new challenges and explore rule-based modelling as a basis for a new generation of synaptic models.

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Molecular Systems Biology of Sic1 in Yeast Cell Cycle Regulation Through Multiscale Modelingen developed to characterize modular networks addressing Sic1 regulatory function. Through complementary experimentation and modeling, we suggest a mechanism that underlies Sic1 function in controlling temporal waves of cyclins to ensure correct timing of the phase-specific Cdk activities.

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Proteome-Wide Screens in , Using the Yeast GFP Collectionbation. However, proteome-wide, cell biological screens are extremely challenging, from both a technical and computational perspective. The yeast GFP collection, an elegant and unique strain set, is ideal for studying both protein localization and abundance across the proteome (.). In this chapter,

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