Titlebook: Advances in Research on Neurodegeneration; Volume 7 Y. Mizuno,D. B. Calne,M. B. H. Youdim Conference proceedings 2000 Springer-Verlag Wien

泥土謙卑

AND

Huntington disease: new insights on the role of huntingtin cleavage,ragments into the nucleus of striatal neurons. Increasing nuclear localization of huntingtin N-terminal fragments within medium spiny neurons of the striatum occurs concomitantly with the onset of selective neurodegeneration. Because huntingtin is a caspase substrate and truncated huntingtin fragmen

Collected

,Autosomal-dominantly inherited forms of Parkinson’s disease,ce and typical Lewy-body pathology (PARK 1), and mutations have been identified in the gene for α-synuclein in these kindreds. Two other loci in families with dominant inheritance have been mapped, to chromosome 2p13 (PARK 3) and to chromosome 4p, respectively. A gene causing autosomal recessive par

hematuria

,Subcellular localization of α-synuclein in primary neuronal cultures: effect of missense mutations,n appears to aggregate into distinct punctate inclusions in the cytoplasm and proximal neurites. Unlike Lewy bodies, these structures are not ubiquitin positive. These regions of α-synuclein accumulation are observed following transfections with wild-type, Ala30Pro or Ala53Thr α-synuclein; neither m

戲法

Iron chelating, antioxidant and cytoprotective properties of dopamine receptor agonist; apomorphinehat continuous sustained stimulation of dopamine receptor may be responsible for its unusual pharmacological activity. Apomorphine has a far more broad neuroprotective activity in the various models as compared with 1-selegiline and may therefore be an ideal drug to study neuroprotection in parkinso

命令變成大炮

white-matter

indubitable

invulnerable

Influx

Mechanisms of tissue injury in multiple sclerosis: opportunities for neuroprotective therapy,of therapeutic delivery systems, which would reach the site of disease activity within the CNS, will permit the administration of inhibitors either of the cell death pathway or of effector target inter action and opens new avenues to neuroprotection approach.