Titlebook: Advances in Research on Neurodegeneration; Volume 10 R. Horowski,Y. Mizuno,M. B. H. Youdim Conference proceedings 2003 Springer-Verlag Wien

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CHIP

What have we learnt from CDNA microarray gene expression studies about the role of iron in MPTP inds animal models, MPTP (N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) and 6-hydroxydopamine. The advent of cDNA microarray gene expression where expression of thousands of genes can be globally assessed has indicated that mechanism of neurodegeneration by MPTP is a complex cascade of vicious circles.

FIR

,Animal models of Parkinson’s disease in rodents induced by toxins: an update,on’s disease. Such models should reproduce the main characteristics of the disease, such as a selective lesion of dopaminergic neurons that evolves over time and the presence of neuronal inclusions known as Lewy bodies. Optimally, such models should also reproduce the lesion of non-dopaminergic neur

Medley