Titlebook: Advances in Rapid Sex-Steroid Action; New Challenges and N Gabriella Castoria,Antimo Migliaccio Book 2012 Springer Science+Business Media,

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Cross Talk Between ERα and Src Signaling and Its Relevance to ER Status and Hormone Responsivenessus, the function of ER may not be solely dependent on the steady state levels of ER protein. A subset of ER negative breast cancers that have ER mRNA but lack detectable ER protein levels may ultimately prove to be responsive to estrogen. These observations may have broader implications for estrogen

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Sex-Steroid Rapid Action and Its Role in Invasiveness and Metastasis of Breast Cancered during exposure to estrogen or other steroids, which indicate that these steroids are powerful regulators of cell movement. Many of these actions are enacted via the rapid activation on extra-nuclear signaling cascades of sex steroid receptors that lead to the recruitment of small GTPases such as

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Unraveling the Role of GPER in Breast Cancerutic strategies against the development of breast cancer. Furthermore, the promiscuous activity exerted by antiestrogens, which act as GPER agonists and antagonists of the nuclear estrogen receptors, addresses the need of new selective estrogen receptor inhibitors.

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Micropatterned Surfaces as Tools for the Study of the Rapid Non-Genomic Actions of Steroid Receptorsptors at the membrane due to their dynamic behaviour, subcellular sizes and complexity of action. Here we describe a novel technique for studying the non-genomic action of steroid hormones making use of dip-pen nanolithography (DPN) for patterning supported lipid bilayers containing haptenated lipid

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Mechanisms of Signal Transduction in Prostate Cancer: The Role of PI3-Kinase Pathway in Androgen Act