| 期刊全稱 | Advances in Biology and Therapy of Multiple Myeloma | | 期刊簡稱 | Volume 1: Basic Scie | | 影響因子2023 | Nikhil C. Munshi,Kenneth C. Anderson | | 視頻video | http://file.papertrans.cn/147/146911/146911.mp4 | | 發(fā)行地址 | Focuses on biology of MM especially, oncogenomic changes, cell signaling pathways and intermediate molecules that are being investigated for development of novel therapies.Explores all clinically impo | | 圖書封面 |  | | 影響因子 | Despite the advances in conventional, novel agent and high dose chemotherapy multiple myeloma (MM) remains incurable. In order to overcome resistance to current therapies and improve patient outcome, novel biologically-based treatment approaches are being developed. Current translational research in MM focusing on the development of molecularly-based combination therapies has great promise to achieve high frequency and durable responses in the majority of patients. Two major advances are making this goal possible. First, recent advances in genomics and proteomics in MM have allowed for increased understanding of disease pathogenesis, identified novel therapeutic targets, allowed for molecular classification, and provided the scientific rationale for combining targeted therapies to increase tumor cell cytotoxicity and abrogate drug resistance. Second, there is now an increased understanding of how adhesion of MM cells in bone marrow (BM) further impacts gene expression in MM cells, as well as in BM stromal cells (BMSCs). As a result of these advances in oncogenomics on the one hand and increased understanding of the role of the BM in the pathogenesis of MM on the other, a new treatm | | Pindex | Book 2013 |
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