Titlebook: Advanced Methods of Pharmacokinetic and Pharmacodynamic Systems Analysis; David Z. D’Argenio Book 1991 Springer Science+Business Media New

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書目名稱Advanced Methods of Pharmacokinetic and Pharmacodynamic Systems Analysis讀者反饋




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hematuria

Binary Liquid Systems of Nonelectrolytes III) observed from relevant noxious stimuli to define clinical anesthetic depth. Finally, it is also possible to relate the EEG measure of anesthetic drug effect to the clinically-observed measures of anesthetic depth.

innovation

Property Groups and Property Types,ach; 2) the definition of a sampling compartment from which elimination occurs does not allow for a differentiation between sampling upstream or downstream of the elimination site, which leads to inconsistencies in the definition of the volume of distribution, .. [3].

enumaerate

Binary Liquid Systems of Nonelectrolytes IIIlinear dependance on clinically relevant concentrations of volatile anesthetics over a physiological range of temperatures. The probe has been tested in both gas and liquid phases, and should operate in blood and tissue, allowing development of a practical device for rapid . monitoring of general anesthetics.

tympanometry

Binary Liquid Systems of Nonelectrolytes IIIct individual tissue drug concentrations, and to investigate alterations in physiological parameters on drug disposition. The advantages of PB-PK modeling are counterbalanced by variable parameter estimation methods, lack of uniform model discrimination methods and requirement of large data bases for either model development or validation.

神秘

Property Groups and Property Types,use of the plasma (blood) or central compartment concept in multi-compartmental or noncompartmental analysis [8–12] in the last several decades has undoubtedly contributed to the general acceptance of the above assumption.

規(guī)范就好

fluoroscopy

Property Groups and Property Types,d an optimal sampling time of.where .. is the average population value of the elimination rate constant. These analyses generally utilize a localized linearization argument, which is strictly valid only in the limit as the population variance of the rate constant approaches zero.

發(fā)出眩目光芒

Property Groups and Property Types,les for maximal information. By varying the class of admissible controls, different strategies are generated. Control strategies to be discussed include: open loop, open loop feedback, separation principle, and iteration in policy space. Monte Carlo simulation studies of a terminal cost type problem are presented.

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