Titlebook: Adjuvant Therapy of Primary Breast Cancer VI; Hans-J?rg Senn,Richard D. Gelber,Beat Thürlimann Conference proceedings 1998 Springer-Verlag

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Tony Pourmohamad,Herbert K. H. Lee research before it can be of practical use. The reason for the silence is the high cost of the technology involved, putting it out of the reach of most academic centres. With the realisation that all of the human genes will be known and sequenced in the next few years, the next objective is to harn

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https://doi.org/10.1007/978-3-319-21921-9ibility allele. Two breast cancer susceptibility genes (BRCA1 and BRCA2) now have been identified (Miki et al. 1994; Wooster et al. 1995; Tavtigian et al. 1996) and a third (BRCA3) is being actively sought. Breast cancer susceptibility in families with mutations in these genes appears as an autosoma

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Planning for Reliability Data Collection,atients today. Adjuvant therapy is only worthwhile if the improvement in outlook is great enough to more than balance the cost and toxicity of therapy. The questions to be addressed are not only whether adjuvant therapy should be given at all, but also which therapy. For example, would the increment

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Regression Models in Reliability,ed 15 or 20 years ago, the answer would have been a simple “no”. At that time, the heterogeneity of the disease was not widely appreciated and most patients with DCIS were treated with mastectomy. The answer today is just as simple, but it is now “yes” rather than no.

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Planning for Reliability Data Collection,through the basement membrane. It is assumed that most, if not all, invasive carcinomas are preceded by DCIS. It is, however, not known what proportion of DCIS, if left untreated, will progress to invasive carcinoma. Approximately 3% of all breast malignancies are DCIS. Because DCIS grows in pre-exi

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Regression Models in Reliability, treated by mastectomy like all other breast cancers. During the intervening years important changes have occurred with regard to both invasive and non-invasive breast cancer. In particular, several trials have demonstrated the safety of breast conservation therapy for selected patients with unifoca