Titlebook: Adeno-Associated Virus Vectors; Design and Delivery Michael J. Castle Book 2019 Springer Science+Business Media, LLC, part of Springer Natu

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https://doi.org/10.1007/978-3-540-49927-5o function of the CNS and finding novel methods for treating neurological disorders have been particularly challenging. One difficulty is correcting genetic disorders afflicting the CNS in a targeted manner. Recombinant adeno-associated viruses (rAAVs) have emerged as promising therapeutic tools for

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Basiswissen Psychiatrie und Psychotherapie Analogous to a lumbar puncture in humans, the rodent spinal cord can be accessed through an efficient, noninvasive injection. Here we describe a method for AAV-mediated gene transfer to cells of the spinal cord by intrathecal injection of small quantities of AAV vector.

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Basiswissen Psychiatrie und Psychotherapieg targeted gene upregulation or silencing in the CNS. Systemic and intrathecal infusion, while preferable routes of vector delivery, have shown encouraging but variable efficacy due to the poor permeability of AAV into spinal cord and brain parenchyma in adult mammals. Recently we have developed a n

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Volker Arolt,Christian Reimer,Horst Dilling using AAV-mediated gene therapy occurred in a mouse model of deafness lacking vesicular glutamate transporter 3 (VGLUT 3). This study utilized a trans-bulla round window membrane (RWM) delivery approach. Since this study, these methodologies have been applied to a number of other mouse models of ge

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Front Matternondestructive testing. This research covers appro- priate testing procedures as well as the algorithms for interpre- tation. In several cases a state has been reached which allows for implementation. The objective of the workshop was to bring together researchers and industrial users of both countr