Titlebook: Acute Promyelocytic Leukemia; A Clinical Guide Oussama Abla,Francesco Lo Coco,Miguel A. Sanz Book 2018 Springer International Publishing AG

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Inferences from Statistics to Causationrobably benefit from prolonged application of ATO. Even after frontline therapy with ATO, salvage therapy with ATO may still be effective. This chapter gives an overview on the currently available treatment options for relapsed APL, as well as on prognostic factors, which may influence the relapse management in the individual patient.

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Causation, Laws and Regularitiesat diagnosis has been utilized to distinguish two risk groups (standard and high risk) on recent pediatric clinical trials to allow risk-adapted therapy. Current research efforts focus on the incorporation of ATO into treatment regimens and further defining risk factors for early death and relapse.

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https://doi.org/10.1007/978-3-031-59135-8causative role in APL pathogenesis [1]. The gene fusion is readily detectable at diagnosis with sensitive PCR techniques and is an extremely reliable target to monitor the residual disease at the molecular level. We will discuss the evolution and importance of minimal residual disease (MRD) monitoring in APL.

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Mary Jean Walker,Wendy A. Rogersderived compounds, all-trans-retinoic acid (ATRA) and arsenic trioxide (ATO). The efficacy of these two agents against the disease and their synergistic and curative potential was predicted by transgenic murine models, which were equally instrumental in unlocking the molecular pathogenesis of APL.

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