| 期刊全稱 | Acute Leukemias IV | | 期刊簡(jiǎn)稱 | Prognostic Factors a | | 影響因子2023 | T. Büchner,W. Hiddemann,J. Ritter | | 視頻video | http://file.papertrans.cn/145/144385/144385.mp4 | | 學(xué)科分類 | Haematology and Blood Transfusion‘ H?matologie und Bluttransfusion | | 圖書封面 |  | | 影響因子 | The rates of acute leukemia cure have gradually improved over the last decade. Clinical study results reflect the impact of chemotherapy intensity and duration, the role of prolonged maintenance, intensified consolidation or very early intensification. Further progress has also been achieved in bone marrow trans- plantation, and recent prospective studies and meta-analyses have contributed comparisons of the high antileukemic efficacy of bone marrow transplantation to that of improved chemotherapy. This allows a more successful combining of the two forms of treatment. New prognostic factors have emerged from both cytogenetic and molecular genetic research. Thus, the Philadelphia chromosome translocation and the bcr/abl gene rearrangement have proven to be the dominating risk factor in acute lymphoblastic leukemia. Since the frequency increases with age, differences in prognosis between children and adults can be explained. Evaluation of molecular and immunologic leukemia cell markers has provided a better understanding of residual leukemia in clinical remission, as a prognostic factor and in monitoring the effectiveness of the antileukemic strategy. Recent work on leukemic cell bio | | Pindex | Conference proceedings 1994 |
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