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Titlebook: ACE Inhibitors; Pedro D’Orléans-Juste,Gérard E. Plante Book 2001 Springer Basel AG 2001 diseases.enzymes.genetics.health policy.heart.meta

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發(fā)表于 2025-3-21 18:42:28 | 只看該作者 |倒序?yàn)g覽 |閱讀模式
期刊全稱(chēng)ACE Inhibitors
影響因子2023Pedro D’Orléans-Juste,Gérard E. Plante
視頻videohttp://file.papertrans.cn/143/142672/142672.mp4
學(xué)科分類(lèi)Milestones in Drug Therapy
圖書(shū)封面Titlebook: ACE Inhibitors;  Pedro D’Orléans-Juste,Gérard E. Plante Book 2001 Springer Basel AG 2001 diseases.enzymes.genetics.health policy.heart.meta
影響因子Angiotensin converting enzyme inhibitors (ACEI) represent the first class of antihypertensive agents that was designed and developed on the basis of a well-defined physiopathological axis of arterial hypertension, a vascular dis- order that is now becoming one of the major causes of morbidity/mortality, not only in developed societies but also in the highly populated developing coun- tries [1]. CAPTOPRIL, the prototype of the "PRIL" family, which now comprises more than 40 molecule-species, was quite hazardous and the clinical develop- ment almost failed when serious side-effects were reported in an alarmist fash- ion in reputable scientific journals, such as the New England Journal of Medicine and Lancet. Squibb & Sons came very close to withdrawing CAPTOPRIL from clinical investigation [2]. However, after re-examination of the data obtained from different categories of patients and appropriate dose-adjustments, the clinical use of CAPTOPRIL turned out to be revolutionary. The prototype, as well as other members of the "PRIL" family became the starting point for numerous basic and clinical research programs, focusing on the interactions of ACEI with the kinin, endothelin, and nitr
Pindex Book 2001
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