Titlebook: A Practical Guide to Drug Development in Academia; The SPARK Approach Daria Mochly-Rosen,Kevin Grimes Book 2023Latest edition The Editor(s)

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https://doi.org/10.1007/978-3-031-34724-5academia; assay design; clinical trial; preclinical drug discovery; translational medicines; target produ

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https://doi.org/10.1007/978-3-030-64922-7s, while also exhibiting the complex array of desired drug-like behaviors that warrant advancement to the clinic. These tasks include target identification and validation, screening for active compounds, chemical modification of candidate compounds to achieve optimized pharmacology, formulating the

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Wyke J. P. Stommel,Martijn W. J. Stommelnd reproducible preclinical pharmacology studies must demonstrate the desired on-target effect; drug formulation and route of administration must be established; pharmacokinetics must be characterized; and preclinical safety studies must be conducted to predict potential drug toxicities and establis

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Statistics for Biology and Healththers may be happy to license their technology and findings to an existing company. In either case, it is essential that your inventions are protected by filing a patent. The next step is finding a commercial partner. This chapter covers important topics that are rarely taught to academic scientists

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Analysis and modelling of lattice data,lated dramatically in recent years. Less profitable indications, even critical needs such as new antibiotics for drug resistant bacterial infections, are largely ignored by the industry. This raises two important questions: (1) Where will our next generation of drugs originate? and (2) How we can we

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