Titlebook: Werner’s Syndrome and Human Aging; Darrell Salk,Yoshisada Fujiwara,George M. Martin Book 1985 The Editor(s) (if applicable) and The Author

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Werner’s Syndrome (Progeria of the Adult) and Rothmund’s Syndrome: Two Types of Closely Related HereObservations on these rare and apparently heredofamilial disorders are scattered throughout the different branches of medical literature according to the particular interest of the individual author specializing in involvement of the eye or the skin or the nervous system.

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Werner’s Syndrome: A Review of its Symptomatology, Natural History, Pathologic Features, Genetics an that the features displayed by the affected members of the family represented a new and distinct entity, he related this condition to one described by Rothmund (106) in which juvenile cataracts were found together with skin changes. The implied association of these two syndromes and the identificat

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Clinical, Endocrine and Metabolic Aspects of the Werner Syndrome Compared with Those of Normal Agingum testosterone concentrations were lower than those in age-matched controls and testicular biopsy revealed more marked atrophy than in aged subjects. Serum triiodothyronine levels tended to be lower than in age-matched controls. Oral glucose tolerance test revealed diabetic glucose tolerance in 55%

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Werner’s Syndrome and Aging: A Reappraisalion mosaicism). The Werner syndrome should not, therefore, be forced into the mold of premature aging but should be studied on its own merits as a condition which may provide us with clues to the pathogenesis of many important problems.

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Cell Fusion Studies in the Werner Syndrometor(s)’ that inhibits their DNA synthesis. We also applied cell hybridization techniques in order to define the genetic defect of WS cells. In this article we will discuss the mechanism of aging in WS in comparison with senescent cells.

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