Titlebook: Oxygen Sensing; Molecule to Man Sukhamay Lahiri,Naduri R. Prabhakar,Robert E. Fors Book 2002 The Editor(s) (if applicable) and The Author(s

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Oxygen Sensing978-0-306-46825-4Series ISSN 0065-2598 Series E-ISSN 2214-8019

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Advances in Experimental Medicine and Biologyhttp://image.papertrans.cn/o/image/705359.jpg

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Evolution of Human Hypoxia Tolerance Physiologytaneously advantageous for endurance performance and for high altitude hypoxia. It is presumed that the phenotype was retained in low capacity form in highlanders and in higher capacity form in most lowland lineages (where it would be recognized by most physiologists as an endurance performance phen

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A Genomic Model for Differential Hypoxic Ventilatory Responses strain distribution pattern (SDP). The SDP for hypoxic . is consistent with the hypothesis that parental strain differences are regulated by two genes. Cosegregation analysis suggest that the genetic control of . during hypoxia differs from the genes which control differential baseline .. Although

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Regulation of the Hypoxia-Inducible Factor-1αunit, suggesting that heterodimerization is required for stable association within the nuclear compartment. Nuclear stabilization of the heterodimer might also explain the hypoxically increased total cellular ARNT levels observed in some of the cell lines examined.

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