標(biāo)題: Titlebook: Use and Approval of Antihypertensive Agents and Surrogate Endpoints for the Approval of Drugs Affect; Proceedings of the T Joel Morganroth, [打印本頁] 作者: CLIP 時(shí)間: 2025-3-21 19:28
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作者: 愛得痛了 時(shí)間: 2025-3-21 21:16
real-time controller implementation.The first comprehensive.Flexible mechanical systems experience undesirable vibration in response to environmental and operational forces. Vibrations can limit the accuracy of sensitive instruments or cause significant errors in applications where high-precision p作者: 閃光東本 時(shí)間: 2025-3-22 03:19 作者: Horizon 時(shí)間: 2025-3-22 06:24 作者: 無辜 時(shí)間: 2025-3-22 09:33 作者: 使高興 時(shí)間: 2025-3-22 16:15 作者: Exposition 時(shí)間: 2025-3-22 20:07
gents act by inhibiting melanogenesis, interrupting melanosome transfer, accelerating epidermal desquamation with melanin turnover, antioxidant effects and by other methods. The topical agents that act mainly by inhibiting melanogenesis through tyrosinase inhibition include hydroquinone and derivati作者: LAP 時(shí)間: 2025-3-22 21:36
Aram V. Chobanian M.D.ssociation may eventuate to the injury of the hosting organism. Parasites may be grouped in .- and .. Infections with endoparasites can cause systemic diseases with possible dermatological signs, whereas infestations with ectoparasites only cause cutaneous lesions. The burden of parasitoses often re作者: Suppository 時(shí)間: 2025-3-23 01:31 作者: 挖掘 時(shí)間: 2025-3-23 08:14
N. M. Kaplanfferent between insects and vertebrates. Insect pigments have been traditionally classified into the following eight classes: melanins, ommochromes, pteridines, tetrapyrroles, carotenoids, flavonoids, papiliochromes, and quinones. Among them, melanins, ommochromes, and pteridines are three major pig作者: BLA 時(shí)間: 2025-3-23 11:04
Harold K. Marder M.D.,Gary Littman Ph.D.eschrijft de neurofysiologie van acute en chronische pijn en de basisprocessen die hierbij optreden. De plasticiteit van het zenuwstelsel zorgt ervoor dat de neurofysiologische mechanismen van chronische pijn heel anders verlopen dan bij acute pijnsensatie. Zo vinden er tijdens een toestand van cent作者: Monolithic 時(shí)間: 2025-3-23 17:04 作者: CAMP 時(shí)間: 2025-3-23 18:38 作者: palette 時(shí)間: 2025-3-24 02:11 作者: Alopecia-Areata 時(shí)間: 2025-3-24 03:47
Milton Packer M.D.ust 1900, at the second International Congress of Mathematicians (ICM) held in Paris, Hilbert proposed a list of 23 problems which, according to him, will have profound value for the progress of mathematical sciences. The seventh problem in the list was?titled, “irrationality and transcendence of ce作者: HALO 時(shí)間: 2025-3-24 07:46
Developments in Cardiovascular Medicinehttp://image.papertrans.cn/u/image/944425.jpg作者: alcoholism 時(shí)間: 2025-3-24 12:07 作者: Licentious 時(shí)間: 2025-3-24 18:02 作者: 規(guī)范就好 時(shí)間: 2025-3-24 22:30 作者: 領(lǐng)巾 時(shí)間: 2025-3-25 01:51 作者: vitreous-humor 時(shí)間: 2025-3-25 05:03 作者: candle 時(shí)間: 2025-3-25 09:15
Do We Need Any More Antihypertensive Drugs: The Validity of a Change in Blood Pressure as the Only Ethere is a hierarchy of possible and potential endpoints beyond simple antihypertensive efficacy than can be considered as criteria for approvability (Table). Brief consideration will be given to each of these, starting from the bottom and proceeding upward.作者: 音的強(qiáng)弱 時(shí)間: 2025-3-25 12:46
The Cost and Time to Develop a New Antihypertensive Drug Depending upon the Endpointy differ among companies due to unique perspectives and practices within the company; however, most often, the plans follow guidelines for drug development that are issued by the Food and Drug Administration.作者: Apraxia 時(shí)間: 2025-3-25 19:05 作者: Benzodiazepines 時(shí)間: 2025-3-25 23:33
Is Ambulatory Blood Pressure Monitoring Required to Define the Hypertensive Patient and to Detect EfBP measurements outside of the medical care environment. During the past 20 years, automatic portable recorders have been developed which have greatly aided in assessing blood pressure during the day and night (1–3). There are a number of advantages of automatic ambulatory blood pressure monitoring 作者: 豎琴 時(shí)間: 2025-3-26 01:27
Is It Necessary to Demonstrate Changes in Left Ventricular Hypertrophy in the Evaluation of Antihypectice, this is unlikely to be achieved. The large scale clinical studies of the benefits of treating hypertension have produced findings that are both confusing and disappointing (1). While there is general consensus that any effective antihypertensive drug is likely to lower the prevalence of strok作者: Ceramic 時(shí)間: 2025-3-26 05:09 作者: inculpate 時(shí)間: 2025-3-26 10:28
How Does One Define Dose-Duration of an Antihypertensive Drug? What is the Role of Non-Mem and the Plled trials that demonstrate an antihypertensive effect in a general population of patients with essential hypertension, and that the dosing interval for the antihypertensive effect be clear. The antihypertensive effect is taken simply as a reflection of a change in blood pressure in comparison to p作者: collagen 時(shí)間: 2025-3-26 13:32
What Have We Learned from Prior Clinical Trials of Antihypertensive Drug Therapy?lopment of cardiovascular complications. The data differ somewhat according to the degree of severity of hypertension, and the findings in patients with moderate and severe hypertension (diastolic blood pressures 105–114 mmHg and ≥ 115 mmHg, respectively) should best be considered separately from th作者: 新娘 時(shí)間: 2025-3-26 20:44 作者: 反話 時(shí)間: 2025-3-27 00:49 作者: 我的巨大 時(shí)間: 2025-3-27 03:13 作者: outskirts 時(shí)間: 2025-3-27 06:19
What Should be Required for FDA Approvability of a New Antihypertensive Drug? What is the FDA’s Viewe fairly clear. Antihypertensive drugs are approved on the basis of a demonstrated ability to lower blood pressure to a reasonable degree and a reasonably complete characterization of a drug’s pharmacokinetic and pharmacodynamic properties, with particular emphasis on dose-response and on patient ch作者: Derogate 時(shí)間: 2025-3-27 12:24 作者: 徹底明白 時(shí)間: 2025-3-27 15:36 作者: 脫水 時(shí)間: 2025-3-27 20:24 作者: 燒瓶 時(shí)間: 2025-3-27 21:56
0166-9842 al and related health care industries, and members of the Food and Drug Administration to discuss important clinical research issues. The Tenth Annual Symposium on New Drugs addressed the problem of whether it was still appropriate to approve antihypertensive agents soley on the endpoint of lowering作者: nephritis 時(shí)間: 2025-3-28 03:02 作者: 壓碎 時(shí)間: 2025-3-28 06:40
What Should be Required for FDA Approvability of a New Antihypertensive Drug? What is the FDA’s Viewaracteristics that can alter this response. We have not, up to now, sought evidence of diminished end-organ damage or mortality for each new agent, relying instead on the past studies that showed such benefits of lowering blood pressure.作者: Herbivorous 時(shí)間: 2025-3-28 13:46 作者: 楓樹 時(shí)間: 2025-3-28 16:11
Are Specific Studies in Elderly Patients Required for FDA Approvability of a New Antihypertensive Dre features to the pathophysiology of hypertension in older persons; (d) there are age-associated alterations in organ function and body composition which can alter drug disposition and responses, and (e) specific studies are already being conducted.作者: 憤怒歷史 時(shí)間: 2025-3-28 20:50 作者: ELATE 時(shí)間: 2025-3-28 23:05
Is Ambulatory Blood Pressure Monitoring Required to Define the Hypertensive Patient and to Detect Efal clinic blood pressure (casual BP) is that numerous measurements over the day and night are more representative of both the directly-measured BP of an individual and the indexes of target organ damage associated with hypertension (4–6).作者: 不能強(qiáng)迫我 時(shí)間: 2025-3-29 06:15
Is It Necessary to Demonstrate Changes in Left Ventricular Hypertrophy in the Evaluation of Antihype organizing and conducting a clinical trial where cardiovascular morbidity is the end-point makes it highly improbable that the newer agents such as calcium antagonists or angiotensin converting enzyme (ACE) inhibitors will be tested in this way.作者: Licentious 時(shí)間: 2025-3-29 07:25
Are there Valid Surrogate Endpoints for Mortality that can be Used to Evaluate the Effects of Antiaride reasonable predictions of mortality effects at less effort and cost than full-scale controlled, randomized clinical trials with mortality as an end point. This discussion will focus on the question: what surrogate endpoints are valid and sufficient to establish benefit of an antiarrhythmic drug on mortality.作者: Lice692 時(shí)間: 2025-3-29 15:00 作者: 束以馬具 時(shí)間: 2025-3-29 16:16
M. A. Weber,J. M. Neutel,D. H. G. Smithunities to leverage new materials, processes and MEMS technology.? .Piezoresistor Design and Applications is an ideal book for design engineers, process engineers and researchers..978-1-4939-5554-1978-1-4614-8517-9Series ISSN 2198-0063 Series E-ISSN 2198-0071 作者: facetious 時(shí)間: 2025-3-29 22:20 作者: narcotic 時(shí)間: 2025-3-30 03:46
Aram V. Chobanian M.D.rs; in humans they are comprised of two major animal groups, parasitic . and parasitic . [1], whereby parasitic arachnids include ticks and mites. As for the ectoparasitic insects, they are exemplified by mosquitoes, tsetse flies, fleas, and lice (Table 16.1).作者: 胡言亂語 時(shí)間: 2025-3-30 06:20
