標(biāo)題: Titlebook: Urothelial Carcinoma; Methods and Protocol Michèle J. Hoffmann,Nadine T. Gaisa,Thorsten H. Ec Book 2023Latest edition The Editor(s) (if app [打印本頁(yè)] 作者: Hazardous 時(shí)間: 2025-3-21 20:06
書(shū)目名稱Urothelial Carcinoma影響因子(影響力)
作者: 食草 時(shí)間: 2025-3-22 00:07 作者: Exonerate 時(shí)間: 2025-3-22 00:58 作者: SNEER 時(shí)間: 2025-3-22 07:40
A Drug Repurposing Pipeline Based on Bladder Cancer Integrated Proteotranscriptomics Signaturesisease heterogeneity and the limitations of the current therapeutic modalities, such as drug low efficacy and patient resistance acquisition. Drug repurposing is a cost-effective strategy that targets the reuse of existing drugs for new therapeutic purposes. Such a strategy could open new avenues to作者: 榨取 時(shí)間: 2025-3-22 09:06 作者: 驚奇 時(shí)間: 2025-3-22 13:59 作者: glomeruli 時(shí)間: 2025-3-22 19:33
Using Sister Chromatid Exchange Assay to Detect Homologous Recombination Deficiency in Epigeneticalld chromatids and their sisters can be visualized in cells when DNA synthesis in one chromatid is labelled by 5-bromo-2’-deoxyuridine (BrdU). Homologous recombination (HR) is considered as the principal mechanism responsible for the sister chromatid exchange (SCE) upon replication fork collapse, and 作者: d-limonene 時(shí)間: 2025-3-23 00:04
Identification of STAG2-Mutant Bladder Cancers by Immunohistochemistryand are therefore classified as non-muscle-invasive bladder cancer (NMIBC). A minority of tumors are diagnosed after they have invaded the underlying detrusor muscle and are classified as muscle-invasive bladder cancer (MIBC). Mutational inactivation of the STAG2 tumor suppressor gene is common in b作者: Sarcoma 時(shí)間: 2025-3-23 04:59
Genome-Wide CRISPR Screening for the Identification of Therapy Resistance-Associated Genes in Urotheide screening, which has some advantages over other screening methods using chemical DNA mutagens for inducing genetic changes, RNA interference, or arrayed screens. Here we describe the use of genome-wide knockout and transcriptional activation screening enabling the CRISPR-Cas9 system to discover 作者: municipality 時(shí)間: 2025-3-23 08:53
Tissue Slice Culture and Analysis of Tumor-Associated Hyaluronan in Urothelial Carcinomaerized by deregulated hyaluronan metabolism. It is postulated that the deregulated metabolism in cancer tissue is characterized by elevated hyaluronan synthesis and degradation. This results in the accumulation of small hyaluronan fragments in the tumor microenvironment which promotes cancer-related作者: 泥土謙卑 時(shí)間: 2025-3-23 12:07 作者: 作嘔 時(shí)間: 2025-3-23 14:29 作者: Melatonin 時(shí)間: 2025-3-23 19:35
Simplex Droplet Digital PCR Assays for the Detection of TERT Promoter Mutations in Urine Samples for urine (cell-free DNA from the urine supernatant or DNA from exfoliated cells in the urine pellet) has demonstrated promising evidence as putative non-invasive biomarkers for UC detection and monitoring. However, detecting these tumour-derived mutations in urine requires highly sensitive methods, ca作者: 滴注 時(shí)間: 2025-3-24 02:08
Predictive Biomarkers of Response to Neoadjuvant Therapy in Muscle Invasive Bladder Cancerder cancer. Despite a survival benefit, approximately half of patients do not respond to chemotherapy and are exposed potentially unnecessarily to substantial toxicity and delay in surgery. Therefore, biomarkers to identify likely responders before initiating chemotherapy would be a helpful clinical作者: GROVE 時(shí)間: 2025-3-24 03:26
Assessment of PD-L1 Status in Urothelial Canceric urothelial cancer. By PD-1 and PD-L1 inhibition with these drugs, the immune system is supposed to regain the capacity to actively kill cancer cells. Meanwhile, PD-L1 assessment is prescribed for patients not being eligible for platinum-based chemotherapy in first-line settings in metastatic dise作者: 光亮 時(shí)間: 2025-3-24 08:59 作者: 敲竹杠 時(shí)間: 2025-3-24 13:00 作者: Bph773 時(shí)間: 2025-3-24 18:25 作者: 非秘密 時(shí)間: 2025-3-24 21:14
Genome-Wide CRISPR Screening for the Identification of Therapy Resistance-Associated Genes in Urotheresistance mechanisms to CDK4/6 inhibition in bladder cancer along with next-generation sequencing (NGS) analysis. We will describe the approach for transcriptional activation in the bladder cancer cell line T24 and provide guidance on critical points during the experimental workflow.作者: 別名 時(shí)間: 2025-3-25 01:50 作者: Tempor 時(shí)間: 2025-3-25 04:42 作者: 轉(zhuǎn)折點(diǎn) 時(shí)間: 2025-3-25 11:17
Predictive Biomarkers of Response to Neoadjuvant Therapy in Muscle Invasive Bladder Cancerf bladder cancer have shown the potential role for DNA damage repair (DDR) gene alterations and molecular subtypes to guide therapy, but these need validation from prospective clinical trials. This chapter reviews candidate predictive biomarkers of response to neoadjuvant therapy in muscle invasive bladder cancer.作者: Goblet-Cells 時(shí)間: 2025-3-25 13:40 作者: 精確 時(shí)間: 2025-3-25 17:01
Scoring Systems for Immunohistochemistry in Urothelial Carcinomaroscopic evaluation and scoring approaches for immunohistochemical stainings. We focus on commonly used and generally feasible approaches for different cellular compartments and comment on their utility in diagnostics and research practice.作者: labyrinth 時(shí)間: 2025-3-25 20:52 作者: GLEAN 時(shí)間: 2025-3-26 04:05
Characterization of Native COMPASS Complex in Urothelial Carcinoma Cells by Size Exclusion Chromatogons were then separated by 3–8% Tris–acetate gradient polyacrylamide gel and the COMPASS complex subunits KMT2C, UTX, WDR5, and RBBP5 were detected by immunoblotting. In this fashion, the formation of a COMPASS complex could be observed in UC cells with wild-type but not in cells with mutant KMT2C and KMTD.作者: 誘騙 時(shí)間: 2025-3-26 05:25
Tissue Slice Culture and Analysis of Tumor-Associated Hyaluronan in Urothelial Carcinomang of the complex mechanisms of hyaluronan metabolism in cancer, it has been proposed to use precision-cut tissue slice cultures prepared using freshly excised cancer tissue. Here we describe the protocol for establishing tissue slice cultures and analysis of tumor-associated hyaluronan in human urothelial carcinoma.作者: falsehood 時(shí)間: 2025-3-26 12:27
Assessment of PD-L1 Status in Urothelial Cancerystectomy. Several challenges which are highlighted in this chapter affect PD-L1 testing in daily routine including availability of representative tissue materials, inter-observer variability, and different available PD-L1 immunohistochemistry assays with different analytical properties.作者: Banquet 時(shí)間: 2025-3-26 12:44
Methods in Molecular Biologyhttp://image.papertrans.cn/u/image/944364.jpg作者: HEPA-filter 時(shí)間: 2025-3-26 19:37
https://doi.org/10.1007/978-1-0716-3291-8Molecular characterization; Targeted therapy; Carcinogenesis; Bladder microbiome; Personalized medicine作者: 討厭 時(shí)間: 2025-3-26 23:10 作者: GRIEF 時(shí)間: 2025-3-27 03:45
Urothelial Carcinoma978-1-0716-3291-8Series ISSN 1064-3745 Series E-ISSN 1940-6029 作者: pacific 時(shí)間: 2025-3-27 05:53
Michèle J. Hoffmann,Nadine T. Gaisa,Thorsten H. EcIncludes cutting-edge techniques.Provides step-by-step detail essential for reproducible results.Contains key implementation advice from the experts作者: BILIO 時(shí)間: 2025-3-27 13:15
Marika Mokou,Shaman Narayanasamy,Rafael Stroggilos,Irina-Afrodita Balaur,Antonia Vlahou,Harald Misch the role of liquid biopsies in the setting of pancreatic cancer. Although results so far seem promising, more extensive studies are required to establish the clinical utility of CTCs and ctDNA in developing a personalized approach for the management of this malignancy.作者: 煩憂 時(shí)間: 2025-3-27 15:06 作者: 不遵守 時(shí)間: 2025-3-27 20:55
Youngrok Park,Alana Lelo,Brent Harris,Deborah L. Berry,Krysta Chaldekas,Jung-Sik Kim,Todd Waldman profiling using the next generation sequencing technologies when applied to circulating tumor DNA may have utility for subsequent targeted therapies and early detection of recurrence. Metastatic PDAC is not surgically resectable. In rare instances however, metachronous, solitary lung nodules may be considered for preoperative therapy.作者: 外向者 時(shí)間: 2025-3-27 22:59
Csilla Olah,Tibor Szarvasso, the various stresses on the beta cell that may lead to the onset of type 2 diabetes will be outlined and the inflammatory signaling pathways that contribute to increased beta-cell apoptosis/necrosis examined.作者: 講個(gè)故事逗他 時(shí)間: 2025-3-28 05:48 作者: Genetics 時(shí)間: 2025-3-28 07:21
Maria Zvereva,Md Ismail Hosen,Nathalie Forey,Mahdi Sheikh,Caroline Kannengiesser,Ibrahima Ba,Arnaud able .. The term ‘pancreatoblastoma’ was proposed to indicate the primitive or blastomatous nature of the tumor in line with the better known solid embryonic neoplasms of childhood, i.e., nephroblastoma, neuro-blastoma and hepatoblastoma. Other authors have similarly equated the pancreatoblastoma and infantile type of pancreatic carcinoma [5, 6].作者: Offset 時(shí)間: 2025-3-28 12:12 作者: 松果 時(shí)間: 2025-3-28 17:56 作者: fertilizer 時(shí)間: 2025-3-28 19:03 作者: 顯赫的人 時(shí)間: 2025-3-28 23:35
Veronika Bahlinger,Arndt Hartmann,Markus Eckstein in vitamin B-12 malabsorption associated with pancreatic insufficiency, and not in pernicious anemia. There is no known method other than the administration of pancreatic extracts to correct this problem..作者: Ruptured-Disk 時(shí)間: 2025-3-29 04:42
cillary methods for the diagnosis of pancreatic ductal adenocarcinoma and cholangiocarcinoma in both fine needle aspiration biopsy and pancreatico-biliary duct fluid, washing, and brushing specimens. Ancillary studies for the diagnosis of other neoplasms are also discussed, as well as precursor lesions of pancreatic ductal adenocarcinoma.作者: Schlemms-Canal 時(shí)間: 2025-3-29 09:51
signatures that may be involved in T1D. Many miRNAs, and potentially other small regulatory RNA molecules discussed through this chapter, are involved in immune regulation and modulation, which may provide novel diagnostic, prognostic and therapeutic alternatives for Type 1 diabetes (T1D) in future.作者: 反對(duì) 時(shí)間: 2025-3-29 12:24 作者: 躲債 時(shí)間: 2025-3-29 18:19 作者: forager 時(shí)間: 2025-3-29 23:22 作者: 作繭自縛 時(shí)間: 2025-3-30 00:47 作者: Thrombolysis 時(shí)間: 2025-3-30 05:34
