標(biāo)題: Titlebook: Synthesis of Therapeutic Oligonucleotides; Satoshi Obika,Mitsuo Sekine Book 2018 Springer Nature Singapore Pte Ltd. 2018 Therapeutic oligo [打印本頁(yè)] 作者: FETUS 時(shí)間: 2025-3-21 16:50
書(shū)目名稱Synthesis of Therapeutic Oligonucleotides影響因子(影響力)
書(shū)目名稱Synthesis of Therapeutic Oligonucleotides影響因子(影響力)學(xué)科排名
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書(shū)目名稱Synthesis of Therapeutic Oligonucleotides網(wǎng)絡(luò)公開(kāi)度學(xué)科排名
書(shū)目名稱Synthesis of Therapeutic Oligonucleotides被引頻次
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書(shū)目名稱Synthesis of Therapeutic Oligonucleotides讀者反饋
書(shū)目名稱Synthesis of Therapeutic Oligonucleotides讀者反饋學(xué)科排名
作者: spinal-stenosis 時(shí)間: 2025-3-21 22:50 作者: 原始 時(shí)間: 2025-3-22 02:19 作者: Sinus-Node 時(shí)間: 2025-3-22 06:38
Masaki Tsukamoto,Yoshihiro Hayakawaent works have shown promising results by using Deep Reinforcement Learning (DRL) techniques to learn socially-aware navigation policies, most approaches are limited to local, short-term navigation. For more complex settings, DRL approaches rely on subgoals often computed using traditional path plan作者: GENRE 時(shí)間: 2025-3-22 09:07
Mitsuo Sekinepatients. The mind robotic rehabilitation is developed based on non-invasive motor imagery brain computer interface (BCI) technology. The use of a spatial filtering algorithm, common spatial pattern (CSP), is proposed for extracting features that maximize the discrimination of two different brain st作者: crescendo 時(shí)間: 2025-3-22 16:08
Hidetoshi Kitagawahuman-human conversations. We then employed raters to estimate how easy it was to interrupt each participant in the video. At the same time, we gathered behavioral information about the collocutors (presence of speech, head pose and gaze direction). After establishing that the raters’ ratings were s作者: 有發(fā)明天才 時(shí)間: 2025-3-22 18:11 作者: Afflict 時(shí)間: 2025-3-23 00:45
Eduardo Paredes,Tatsuya Konishibility arising from the use of socially intelligent robots i.This book presents a comprehensive overview of the human dimension of social robots by discussing both transnational features and national peculiarities. Addressing several issues that explore the human side of social robots, this book inv作者: 狂熱文化 時(shí)間: 2025-3-23 04:47 作者: glacial 時(shí)間: 2025-3-23 09:16
Kohji Seio,Mitsuo Sekineace with users. From the point of view of design culture, humanoid artifacts, are at the intersection of product design, visual communication, and interaction design. The release of open hardware platforms, such as Arduino Robot, as well as the diffusion of fabrication laboratories (fablabs) and ope作者: 松軟無(wú)力 時(shí)間: 2025-3-23 12:59
Yoshiyuki Hari powerful but unobtrusive form of communication between humans and robots. The capabilities of robots are expanding, which entails a need to improve and increase the perception of all possible communication channels. Therefore, the modalities of text- or speech-based communication have to be extende作者: 疼死我了 時(shí)間: 2025-3-23 16:43
Noriko Saito-Tarashima,Akira Matsuda,Noriaki Minakawa powerful but unobtrusive form of communication between humans and robots. The capabilities of robots are expanding, which entails a need to improve and increase the perception of all possible communication channels. Therefore, the modalities of text- or speech-based communication have to be extende作者: Pudendal-Nerve 時(shí)間: 2025-3-23 19:00
Takashi Sakamoto,Kenzo Fujimotothesis, the statistical hypotheses, the possible types of errors, and the significance level. Hypothesis testing is then illustrated step by step using two examples. Since there are a number of different tests available, it is also discussed which test is suitable for which purpose. This should enab作者: 1分開(kāi) 時(shí)間: 2025-3-23 22:52 作者: 止痛藥 時(shí)間: 2025-3-24 02:46
Noriaki Minakawa,Noriko Saito-Tarashima,Akira Matsudaficulties come together. I will focus on those dynamics where we make a distinction between a micro level of individual behavior and a macro level with macro effects. A . problem is that there is no well accepted theoretical micro foundation of human behavior. Sometimes individuals are looking sidew作者: 一加就噴出 時(shí)間: 2025-3-24 09:18 作者: 讓步 時(shí)間: 2025-3-24 14:39 作者: Awning 時(shí)間: 2025-3-24 15:28
Recent Development of Chemical Synthesis of RNAs in the coupling efficiency and suppression of side reactions during RNA synthesis cycles are described in great detail. The methods and associated problems for constructing the key synthetic intermediates, i.e., 2′-.-protected ribonucleoside 3′-phosphoramidite building blocks, are also discussed.作者: 類似思想 時(shí)間: 2025-3-24 21:57 作者: UTTER 時(shí)間: 2025-3-25 01:04
Chemical Synthesis of Boranophosphate Deoxy-ribonucleotidesy for gene suppression. Over past two decades, chemists have tried to develop an efficient method for the chemical synthesis of boranophosphate deoxyribonucleotides. In this review, recent studies on the synthesis of boranophosphate deoxyribonucleotides are focused.作者: expansive 時(shí)間: 2025-3-25 05:01
Non-protected Synthesis of Oligonucleotides–N bond cleavage using 6-nitro-HOBt is more than 99% in the RNA synthesis without base protection. In this review, we summarize the .-selective phosphorylation in DNA and RNA synthesis without base protection and the synthesis of modified oligonucleotides having alkaline-labile functional groups using these new methods.作者: Indebted 時(shí)間: 2025-3-25 09:40 作者: 榮幸 時(shí)間: 2025-3-25 14:26
Book 2018tic potential. Nucleic acid-based therapeutics are attracting much attention, and numerous therapeutic oligonucleotides, such as antisense oligonucleotides, siRNAs, splice-switching oligonucleotides, and nucleic acid aptamers, are being evaluated in clinical trials for the treatment of a variety of 作者: 可以任性 時(shí)間: 2025-3-25 18:29
Nucleosides and Oligonucleotides Incorporating 2-Thiothymine or 2-Thiouracil Derivatives as Modifiede physicochemical properties of thio-modified bases and the methods for the syntheses of 2-thiouridine and 2-thiothymidine are described. In addition, the solid-phase synthesis of oligonucleotides incorporating these thio-nucleosides is described.作者: Accolade 時(shí)間: 2025-3-25 20:58
Site-Specific Modification of Nucleobases in Oligonucleotides, the site-specific modifications focusing on nucleobases within oligonucleotides are summarized. Moreover, as an experimental example of site-specific modification of an oligonucleotide, the preparation of .,.-disubstituted cytosine derivatives using reaction of 4-triazolylpyrimidin-2-one nucleobase with various secondary amines is demonstrated.作者: demote 時(shí)間: 2025-3-26 03:11 作者: Cholesterol 時(shí)間: 2025-3-26 08:20 作者: MIRE 時(shí)間: 2025-3-26 11:04
Photo-Cross-Linkable Artificial Nucleic Acid: Synthesis and Properties of 3-Cyanovinylcarbazole-Modiith their complementary nucleic acid within a few seconds of photoirradiation are examined. The details of the synthetic method, properties and the applications for regulating gene expression in cells are discussed.作者: Affirm 時(shí)間: 2025-3-26 15:06 作者: 都相信我的話 時(shí)間: 2025-3-26 17:31
and inspire fresh ideas in nucleic acid chemistry.Meets the .This book presents the latest knowledge on a broad range of topics relating to the synthesis of natural and artificial oligonucleotides with therapeutic potential. Nucleic acid-based therapeutics are attracting much attention, and numerous作者: chuckle 時(shí)間: 2025-3-26 22:06 作者: 小官 時(shí)間: 2025-3-27 04:37
Various Coupling Agents in the Phosphoramidite Method for Oligonucleotide Synthesisthe most widely employed method for the chemical synthesis of oligodeoxyribonucleotides and oligoribonucleotides, and it describes their utility, efficiency, and drawbacks. Moreover, the mechanism of the coupling of the nucleoside phosphoramidite and nucleoside promoted by the coupling agent is disc作者: 轉(zhuǎn)換 時(shí)間: 2025-3-27 07:33 作者: 車床 時(shí)間: 2025-3-27 12:19 作者: itinerary 時(shí)間: 2025-3-27 15:33
Liquid-Phase Synthesis of Oligonucleotidest applies our original liquid-phase synthesis technology for practical use..Recent progress in various types of oligonucleotide therapeutics, such as antisense, aptamer, siRNA and miRNA, has led to growing demand for economical and/or large scale production. Conventionally-known solid-phase synthesi作者: 卜聞 時(shí)間: 2025-3-27 21:42 作者: exceptional 時(shí)間: 2025-3-28 00:02
Nucleosides and Oligonucleotides Incorporating 2-Thiothymine or 2-Thiouracil Derivatives as Modifiedinity and base discrimination ability. For the incorporation of these thio-bases into oligonucleotides, efficient methods for the synthesis of thio-modified nucleosides and the incorporation of the thio-nucleosides into oligonucleotides under solid-phase conditions are necessary. In this chapter, th作者: overwrought 時(shí)間: 2025-3-28 05:29 作者: 掃興 時(shí)間: 2025-3-28 08:33
Four-Hydrogen-Bonding Base Pairs in Oligonucleotides: Design, Synthesis, and Propertiesion have been designed and prepared to address the fundamental question: why did Watson–Crick base pairs come to contain two or three H-bonds during the evolution of life? As the first generation of four-H-bonding base pairs, imidazo[5′,4′:4,5]pyrido[2,3-.]pyrimidine (.) was selected as an aglycon t作者: Maximizer 時(shí)間: 2025-3-28 12:41
Photo-Cross-Linkable Artificial Nucleic Acid: Synthesis and Properties of 3-Cyanovinylcarbazole-Modimporally due to its sequence specificity and high photo irradiation operability. Therefore, photo-cross-linkable artificial nucleic acids are required to be specific and effective drugs without adverse effects and also be good tools for investigating gene functions in cells..As one of the most react作者: 外科醫(yī)生 時(shí)間: 2025-3-28 16:56
Effects of 2′-,-Modifications on RNA Duplex Stabilityecause of their facile synthetic accessibility and large influence on the biological and physical properties of RNA duplexes. This chapter focuses on the effects of chemical modifications on RNA duplex stability. The effects of the 2′-hydroxyl modifications on preorganization of the RNA backbone and作者: 植物茂盛 時(shí)間: 2025-3-28 20:54
2′,4′-Bridged Nucleic Acids Containing Plural Heteroatoms in the Bridge Moietyd many classes of 2′,4′-bridged nucleic acids have been developed to date. Evaluation of oligonucleotides containing 2′,4′-bridged nucleic acids suggests that, in addition to the bridge size, the number, type, and position of atoms composing the bridge unit affect (i) the binding affinity to target 作者: CHYME 時(shí)間: 2025-3-28 23:00
Synthesis and Therapeutic Applications of Oligonucleotides Containing 2′-,,4′-,-Ethylene- and 3′-,,4taining 2′-.,4′-.-ethylene-bridged nucleic acid (ENA) have been synthesized as functional oligonucleotides to further optimize the 2′-.,4′-.-methylene-linkage of bridged nucleic acids (2′,4′-BNA) or locked nucleic acids (LNA). Oligonucleotides containing ENA residues show three notable properties: (作者: Conserve 時(shí)間: 2025-3-29 04:34 作者: phlegm 時(shí)間: 2025-3-29 08:56
Development of Triplex Forming Oligonucleotide Including Artificial Nucleoside Analogues for the Antf gene expression and sequencing technologies. In an antiparallel triplex DNA, a purine-rich triplex forming oligonucleotide (TFO) consisting of a dG, dA or T forms two reverse Hoogsteen hydrogen bonds with a GC, AT or AT base pair of the duplex DNA, respectively, with a high selectivity in a sequen作者: 平躺 時(shí)間: 2025-3-29 15:02
Chemical Synthesis of Boranophosphate Deoxy-ribonucleotidesare useful as therapeutic agents owing to affinity for complementary RNA, nuclease resistance, RNase H activity, efficient cellular uptake, and potency for gene suppression. Over past two decades, chemists have tried to develop an efficient method for the chemical synthesis of boranophosphate deoxyr作者: Expertise 時(shí)間: 2025-3-29 15:42
Springer Nature Singapore Pte Ltd. 2018作者: 哪有黃油 時(shí)間: 2025-3-29 21:38
http://image.papertrans.cn/t/image/884313.jpg作者: 不遵守 時(shí)間: 2025-3-30 01:22 作者: 星球的光亮度 時(shí)間: 2025-3-30 07:44 作者: CEDE 時(shí)間: 2025-3-30 10:26 作者: Acetaldehyde 時(shí)間: 2025-3-30 14:07 作者: 同音 時(shí)間: 2025-3-30 16:35 作者: bifurcate 時(shí)間: 2025-3-30 22:04
Synthesis and Therapeutic Applications of Oligonucleotides Containing 2′-,,4′-,-Ethylene- and 3′-,,4taining 3′-.,4′-.-propylene linkage can be incorporated into the third position of 2′,5′-oligoadenylate (2-5A) to maintain biological activities with nuclease resistance. This modified 2-5A with 3′-.,4′-.-propylene adenosine could be useful for novel anti-cancer and anti-viral reagents as an RNase L作者: 針葉類的樹(shù) 時(shí)間: 2025-3-31 04:50
RNA Bioisosteres: Chemistry and Properties of 4′-thioRNA and 4′-selenoRNAd nuclease resistance, as well as biocompatibility with natural RNA, and was used effectively as a chemically modified siRNA and for isolation of 4′-thioRNA aptamers. Current progress in the development of a new RNA bioisostere 4′-selenoRNA, which contains a selenium atom, is also described.作者: cajole 時(shí)間: 2025-3-31 09:00
Book 2018esh ideas in nucleic acid chemistry that may ultimately lead to novel concepts and techniques and the discovery of more effective nucleic acid drugs. The book will be of high value for both established researchers in the field and students intending to specialize in nucleic acid chemistry research. 作者: 貧窮地活 時(shí)間: 2025-3-31 11:21 作者: osteocytes 時(shí)間: 2025-3-31 14:12
otics scenarios. To demonstrate the utility of the causal models obtained from real-world datasets, we present a comparison between causal and non-causal prediction approaches. Our results show that the causal model correctly captures the underlying interactions of the considered scenarios and impro作者: ABASH 時(shí)間: 2025-3-31 20:09
