標(biāo)題: Titlebook: Structure–Activity Relationships for Development of Neurokinin-3 Receptor Antagonists; Reducing Environment Koki Yamamoto Book 2020 Springe [打印本頁] 作者: purulent 時(shí)間: 2025-3-21 19:28
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作者: 不愛防注射 時(shí)間: 2025-3-21 20:18
Koki YamamotoNominated as an outstanding Ph.D. thesis by Kyoto University.Presents a new concept of drug design to reduce environmental impact.Shows how structure–activity studies help to design eco-friendly drugs作者: ostensible 時(shí)間: 2025-3-22 01:48 作者: Arb853 時(shí)間: 2025-3-22 07:36
https://doi.org/10.1007/978-981-15-2965-8Drug Design with Reduced Environmental Impact; Structure–activity Relationship Study; Neurokinin-3 Rec作者: 舞蹈編排 時(shí)間: 2025-3-22 10:26 作者: craving 時(shí)間: 2025-3-22 15:29 作者: 不愛防注射 時(shí)間: 2025-3-22 17:04
Development of NK3R Antagonists with a Degradable Scaffold in the Natural Environment: Synthesis anf [1,2,4]triazolo[4,3-.]piperazine derivatives was established based on gold(I)-catalyzed domino cyclization of an amidrazone substrate with a terminal alkyne. The amidoxime congeners were also converted into [1,2,4]oxadiazolo[4,5-.]piperazine derivatives in the presence of a gold catalyst.作者: 毛細(xì)血管 時(shí)間: 2025-3-23 00:29 作者: climax 時(shí)間: 2025-3-23 02:37 作者: GLIDE 時(shí)間: 2025-3-23 06:42 作者: hemophilia 時(shí)間: 2025-3-23 12:21
Book 2020lving scaffold hopping for decomposable motifs, which led to a novel photodegradable NK3R antagonist..?.Demonstrating that it is possible to develop compounds that convert into their inactive forms under environmental conditions, this book is useful for anyone interested in therapeutic agents with r作者: 背書 時(shí)間: 2025-3-23 14:10 作者: 盡忠 時(shí)間: 2025-3-23 21:34
Development of NK3R Antagonists with a Labile Functional Group in the Natural Environment,ited comparable biological activity to that of the parent talnetant. Additionally, 3-mercaptoquinoline was converted into the disulfide or isothiazolone form by air-oxidation, both of which showed no binding affinity to NK3R.作者: 密碼 時(shí)間: 2025-3-24 01:10 作者: Ointment 時(shí)間: 2025-3-24 04:01
Introduction,dients are excreted from the body in an unmetabolized form and/or as active metabolites via urine and/or feces. High chemical stability of the ingredients is crucial for quality control of pharmaceuticals during long-term storage before administration. However, in terms of the impacts on the natural作者: conceal 時(shí)間: 2025-3-24 09:46 作者: CHIDE 時(shí)間: 2025-3-24 11:52 作者: Devastate 時(shí)間: 2025-3-24 17:12
Development of NK3R Antagonists with a Degradable Scaffold in the Natural Environment: Identificati in fezolinetant were designed and synthesized. An isoxazolo[3,4-.]piperidine derivative exhibited moderate NK3R antagonistic activity with the favorable properties decomposable under environmental conditions.作者: nauseate 時(shí)間: 2025-3-24 19:31 作者: inscribe 時(shí)間: 2025-3-25 01:01
Chi Anyansi-Archibonginvestigation limits ecological understanding. One reason for this is that a limited observation set underlies every data gathering process. An.“the phenomena of interest, the specific measurements taken, and the techniques used to analyze the data” (O’Neill et al. 1986, Bissonette this volume). Eve作者: 沙發(fā) 時(shí)間: 2025-3-25 04:16
Stefanie StreckPlatz gegriffen, die, lediglich auf das roheste Lesebedürfnis der Kinder spekulierend, alle feineren Ansprüche sowohl an den Text wie an die Ausstattung in dem heranwachsenden Geschlecht t?tet.? So schreibt der prominenteste Jugendschriftenkritiker und Literaturp?dagoge dieser Epoche, der Hamburger 作者: Harpoon 時(shí)間: 2025-3-25 09:03 作者: Nmda-Receptor 時(shí)間: 2025-3-25 13:02
The Popularization and Development of High School Education in Poor Areas,of nine-year compulsory education, senior high school education is of great significance. At present, China’s senior high school education consists of two types: ordinary senior high school education and secondary vocational school education, which carry on the functions of conveying learning talent作者: defray 時(shí)間: 2025-3-25 16:01
Zu neuen Dispositionene?en, Anordnungen treffen und Auftr?ge erteilen. Dabei haben Sie es sowohl mit den Gegenst?nden als auch mit den zugeh?rigen Mengen zu tun. Auf beiden Ebenen sollten Sie sich für eine Erneuerung interessieren.作者: Volatile-Oils 時(shí)間: 2025-3-25 23:41
Management of Obesity Disorders in Childhood and Adolescence,s like type 2 diabetes mellitus and cardiovascular diseases. Recently, scientific advances have led to an improved understanding of the genome/ epigenome-environment interaction and involved pathways for the regulation of body weight. This knowledge about the genetic/ epigenetic regulation, together作者: motivate 時(shí)間: 2025-3-26 03:04
Forschen,e Beschreibung Kompetenzhinweise sowohl in Verbindung mit der n?heren Absicht als auch hinsichtlich der Bedingungen ihrer Realisierung eingehen. Das entspricht dem Erkl?rungscharakter von Tugendvorstellungen, die sich in diesem Fall auf indirekte Weise mit erfolgreichem Forschen verknüpfen. Wir habe作者: 牌帶來 時(shí)間: 2025-3-26 08:04
Electron Driven Processes,olecular targets in both gaseous and condensed phases if matter. Many of these new studies are at the forefront of modern interdisciplinary research. In this article a brief review of the current state of knowledge in electron scattering will be discussed and a few examples of the new and exciting areas of electron research presented.作者: Fulsome 時(shí)間: 2025-3-26 10:33
Cellular Ultrastructure, living planktic and benthic foraminifers and their relations to other Sarcodina may provide evidence of phylogenetic affinities, and help to elucidate evolutionary origins in concert with data on shell morphology.作者: 糾纏 時(shí)間: 2025-3-26 12:58
tial Analysis and Modelling,4. Global Environmental Change,5. Complex Environment,6. Risk Assessment, Management and Mitigation,7. Social and Economic Impact and Policies.978-3-662-52231-8978-3-642-31337-0作者: mastoid-bone 時(shí)間: 2025-3-26 18:40 作者: 榨取 時(shí)間: 2025-3-26 21:35 作者: pellagra 時(shí)間: 2025-3-27 05:06
Introductionhe study of alkaloids, attention was not paid to orchids as a source of new phytochemicals. That has now changed dramatically, and every month new discoveries are announced. The pharmacological effects of extracts or compounds from various orchids are another area of study. Summaries of these findin作者: GREEN 時(shí)間: 2025-3-27 06:41
Filipino Children and the Affective Economy of Saving and Being Saved: Remittances and Debts in Transnational Migrant Familieswhich, in terms of Southeast Asia, accounts for over half of all remittances (International Fund for Agricultural Development, 2013) and leads as a migrant-sending country to top destinations such as the USA, Saudi Arabia, Canada, Malaysia, Japan, Australia, Italy, Qatar, the UAE and the UK (World Bank, 2011).作者: 威脅你 時(shí)間: 2025-3-27 10:41
Herm. Meyerelements in the current debate that are considered in greater detail in this volume include changing views on (a) centre-local relations with signs of an increasing commitment to decentralisation as a guiding principle for developing school governance; (b) school autonomy which is now increasingly r作者: Guileless 時(shí)間: 2025-3-27 14:47
Book 1978ed common European postgraduate training system for young neurosurgeons and 2. the language barriers, which impede the exchange of neurosurgical findings in Europe more than in other parts of the world. The fact that the English language is well on the way to becoming the international medium at Eur作者: 預(yù)兆好 時(shí)間: 2025-3-27 21:08
