作者: Institution 時間: 2025-3-22 00:10 作者: 無效 時間: 2025-3-22 02:36
Klaus Groschner,Wolfgang F. Graier,Christoph RomanDescribes the role of SOCE pathways in health and disease.Combines basic research with clinical aspects.The second edition was updated with new discoveries in the field of structural biology, optogene作者: Physiatrist 時間: 2025-3-22 05:46
978-3-319-86236-1The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerl作者: Engaged 時間: 2025-3-22 12:17
Store-Operated Ca2? Entry (SOCE) Pathways978-3-319-57732-6Series ISSN 0065-2598 Series E-ISSN 2214-8019 作者: Gyrate 時間: 2025-3-22 16:44
James W. Putneyünftige Computerentwicklung mitgestalten wollen und die den Computereinsatz insbesondere in einer technischen Umgebung sehen. Insofern ist das Buch die ideale Erg?nzung des mehr praktisch orientierten Buches "Mikroprozessortechnik" derselben Autoren.978-3-662-00596-5Series ISSN 0937-7433 Series E-ISSN 2512-5214 作者: 過去分詞 時間: 2025-3-22 17:16
Jinhui Zhu,Qingping Feng,Peter B. Stathopulosünftige Computerentwicklung mitgestalten wollen und die den Computereinsatz insbesondere in einer technischen Umgebung sehen. Insofern ist das Buch die ideale Erg?nzung des mehr praktisch orientierten Buches "Mikroprozessortechnik" derselben Autoren.978-3-662-00596-5Series ISSN 0937-7433 Series E-ISSN 2512-5214 作者: 樂章 時間: 2025-3-22 21:18
Aparna Gudlur,Patrick G. Hoganweiligen Prozessor zugeführt werden, weil dessen Geschwindigkeit anders nicht nutzbar ist. Daraus folgen weitreichende Konsequenzen bezüglich der Software, denn für die vektororientierten Datenbasen ben?tigt man neue Algorithmen. Die Maschinen fanden daher auch zun?chst nur dort Interesse, wo die Be作者: 針葉類的樹 時間: 2025-3-23 02:27
Marc Fahrner,Rainer Schindl,Martin Muik,Isabella Derler,Christoph Romaninweiligen Prozessor zugeführt werden, weil dessen Geschwindigkeit anders nicht nutzbar ist. Daraus folgen weitreichende Konsequenzen bezüglich der Software, denn für die vektororientierten Datenbasen ben?tigt man neue Algorithmen. Die Maschinen fanden daher auch zun?chst nur dort Interesse, wo die Be作者: 自制 時間: 2025-3-23 09:32 作者: Glaci冰 時間: 2025-3-23 13:22
Alexei V. Tepikinassung wird abschlie?end in Abschn. 6.3, als exemplarisches Beispiel, ein konzeptueller Entwurf eines Prozessorkerns durchgeführt und dessen prototypische Implementierung in einem FPGA Baustein dargestellt. Darüber hinaus werden in Abschn. 6.4 die heute gebr?uchlichen Verbindungstechnologien in prog作者: HATCH 時間: 2025-3-23 17:54
The STIM-Orai Pathway: Conformational Coupling Between STIM and Orai in the Activation of Store-Operctivation of Orai1 channel activity. This unimolecular model is strongly supported by evidence of variable STIM1:Orai1 stoichiometry reported in many studies. We hypothesize that unimolecular coupling promotes cross-linking of channels, localizing Ca. signals, and regulating channel activity. We hav作者: prodrome 時間: 2025-3-23 19:56
The STIM-Orai Pathway: Light-Operated Ca2+ Entry Through Engineered CRAC Channels and non-excitable cells. When combined with nanotechnology, it becomes feasible to wirelessly photo-modulate Ca.-dependent activities in vivo. In this chapter, we briefly review most recent advances in engineering CRAC channels to achieve optical control over Ca. signaling, outline their design pri作者: HAVOC 時間: 2025-3-24 00:55
STIM-TRP Pathways and Microdomain Organization: Contribution of TRPC1 in Store-Operated Ca2+ Entry: istinct domain in its C-terminus. However, TRPC1 function depends on Orai1-mediated Ca. entry, which triggers recruitment of TRPC1 into the plasma membrane where it is activated by STIM1. TRPC1 and Orai1 form distinct store-operated Ca. channels that regulate specific cellular functions. It is now c作者: AGONY 時間: 2025-3-24 06:24
New Aspects of the Contribution of ER to SOCE Regulation: TRPC Proteins as a Link Between Plasma Memr store-operated Ca. entry, evidence is growing for STIM-operated TRPC channel activities in various cell types, demonstrating both store-dependent and store-independent mechanisms of TRPC channel gating. The existence of physical and functional interactions between plasma membrane-localized TRPC ch作者: 雜色 時間: 2025-3-24 08:59
The Role of Mitochondria in the Activation/Maintenance of SOCE: Store-Operated Ca2+ Entry and MitochOCE is sensed by mitochondria, and the ensuing mitochondrial Ca. uptake boosts mitochondrial energy metabolism and, if Ca. overload occurs, may even lead to apoptosis or cell death. In several cell types, mitochondria seem to be sterically excluded from the confined space that forms between the plas作者: Generosity 時間: 2025-3-24 10:58
The Role of Mitochondria in the Activation/Maintenance of SOCE: Membrane Contact Sites as Signaling ed by the release of Ca. from acidic stores. Intracellular MCS also regulate the efficiency of phagocytosis, a fundamental cellular process essential for immunity and tissue homeostasis, by ensuring the coordinated opening of Ca. channels on phagocytic vacuoles and of Ca. release channels on juxtapo作者: 松軟 時間: 2025-3-24 15:01 作者: 引起 時間: 2025-3-24 22:23 作者: 冬眠 時間: 2025-3-24 23:19 作者: zonules 時間: 2025-3-25 04:58
Dora Bodnar,Woo Young Chung,Dongki Yang,Jeong Hee Hong,Archana Jha,Shmuel Muallem作者: 同來核對 時間: 2025-3-25 11:17
Hayley Dingsdale,Emmanuel Okeke,Lee Haynes,Gyorgy Lur,Alexei V. Tepikin作者: 假裝是你 時間: 2025-3-25 12:10 作者: Brochure 時間: 2025-3-25 18:15 作者: 高談闊論 時間: 2025-3-25 22:02
The STIM-Orai Pathway: STIM-Orai Structures: Isolated and in Complexhlight structures of human Orai1 N-terminal and C-terminal domains in complex with calmodulin and human STIM1, respectively. Ultimately, the accessible structural data are discussed in terms of potential mechanisms of action and cohesiveness with functional observations.作者: REIGN 時間: 2025-3-26 02:10
STIM-TRP Pathways and Microdomain Organization: Ca2+ Influx Channels: The Orai-STIM1-TRPC ComplexesM1, both channel types function at the ER/PM (plasma membrane) junctions. This chapter describes the properties and regulation of the channels by STIM1, with emphasis how and when TRPC channels function as STIM1-dependent and STIM1-independent modes and their unique Ca.-dependent physiological functions that are not shared with the Orai channels.作者: hypnotic 時間: 2025-3-26 07:34
STIM-TRP Pathways and Microdomain Organization: Auxiliary Proteins of the STIM/Orai Complex the participation of several other components, many of which remain unidentified to this date. Here we review several of the proteins identified as constituents of the so-called store-operated calcium influx complex (SOCIC) and discuss their role in modulating this complex phenomenon.作者: 隼鷹 時間: 2025-3-26 11:45
Introductional Ca. increase), it is vital for the normal functioning of multiple types of cells and tissues, and when misregulated it induces important pathological processes. The reader hopefully agree that such an important “tail” is more appropriate for a kangaroo than for a Chihuahua and that it has awesome wagging capacity.作者: reperfusion 時間: 2025-3-26 15:57 作者: CLOT 時間: 2025-3-26 19:29
The STIM-Orai Pathway: Regulation of STIM and Orai by Thiol Modificationsnvolved in a plethora of cellular responses, the cross-talk between reactive oxygen species (ROS) and Ca. is critical for homeostatic control. Identification of calcium regulatory protein targets of thiol redox modifications is needed to understand their role in biology and disease.作者: 我悲傷 時間: 2025-3-27 00:06 作者: enfeeble 時間: 2025-3-27 05:08 作者: CROW 時間: 2025-3-27 09:18 作者: Friction 時間: 2025-3-27 13:11
The STIM-Orai Pathway: Orai, the Pore-Forming Subunit of the CRAC Channeltudies that implicated Orai as part of the store-operated Ca. entry pathway and as the CRAC channel pore subunit, and finally examines ongoing work that is providing insights into CRAC channel structure and gating.作者: OTTER 時間: 2025-3-27 14:51 作者: ineptitude 時間: 2025-3-27 17:56 作者: Maximize 時間: 2025-3-27 22:23
The STIM-Orai Pathway: STIM-Orai Structures: Isolated and in Complexis for Orai channel activity. This chapter focuses on the available high-resolution structural details of STIM and Orai proteins with respect to the regulation of store-operated Ca. entry (SOCE). Solution structures of the Ca.-sensing domains of STIM1 and STIM2 are reviewed in detail, crystal struct作者: Intruder 時間: 2025-3-28 03:09
The STIM-Orai Pathway: Orai, the Pore-Forming Subunit of the CRAC Channelat Orai is the pore subunit of the CRAC channel. It begins by reviewing briefly the defining characteristics of the CRAC channel, then discusses the studies that implicated Orai as part of the store-operated Ca. entry pathway and as the CRAC channel pore subunit, and finally examines ongoing work th作者: faucet 時間: 2025-3-28 06:24 作者: 定點 時間: 2025-3-28 13:46 作者: Banister 時間: 2025-3-28 15:34
The STIM-Orai Pathway: Regulation of STIM and Orai by Thiol Modificationsange of chemical modifications besides their known role in disulfide formation, such as S-sulfenylation (-SOH), S-sulfinylation (-SO(2)H), S-sufonylation (-SO(3)H), S-glutathionylation (-SSG), and S-sulfhydration (-SSH), among others. These posttranslational modifications can be irreversible and act作者: DEI 時間: 2025-3-28 19:43
The STIM-Orai Pathway: Light-Operated Ca2+ Entry Through Engineered CRAC Channelsxpression, and metabolism. To study the impact of Ca. signals on biological processes, pharmacological tools and caged compounds have been commonly applied to induce fluctuations of intracellular Ca. concentrations. These conventional approaches, nonetheless, lack rapid reversibility and high spatio作者: 教唆 時間: 2025-3-29 01:17
STIM-TRP Pathways and Microdomain Organization: Ca2+ Influx Channels: The Orai-STIM1-TRPC Complexesle cells are the Orai and TRPC families of Ca. channels. These channels are activated in response to cell stimulation and Ca. release from the endoplasmic reticulum (ER). The protein that conveys the Ca. content of the ER to the plasma membrane is the ER Ca. sensor STIM1. STIM1 activates the Orai ch作者: Irascible 時間: 2025-3-29 04:53
STIM-TRP Pathways and Microdomain Organization: Contribution of TRPC1 in Store-Operated Ca2+ Entry: ols the regulation of physiological functions in a wide variety of cell types. The transient receptor potential canonical (TRPC) channels (TRPCs 1–7), which are activated by stimuli leading to PIP. hydrolysis, were first identified as molecular components of SOCE channels. While TRPC1 was associated作者: 通情達(dá)理 時間: 2025-3-29 08:08
STIM-TRP Pathways and Microdomain Organization: Auxiliary Proteins of the STIM/Orai Complex the endoplasmic reticulum (the stores) and a calcium channel immersed on the plasma membrane. These two basic components are STIM and Orai, the most fundamental and minimal molecular constituents of the store-operated calcium entry mechanism. However, even when minimal components can be reduced to 作者: 綠州 時間: 2025-3-29 14:54 作者: OATH 時間: 2025-3-29 15:47
New Aspects of the Contribution of ER to SOCE Regulation: The Role of the ER and ER-Plasma Membrane junctions have specific dimensions and are nonuniformly distributed in polarized cells. The mechanisms involved in the formation of the junctions are currently undergoing vigorous investigation, and significant progress was attained in this research area during the last 10?years. Some cell types di作者: Delude 時間: 2025-3-29 22:06 作者: 約會 時間: 2025-3-30 02:14 作者: bifurcate 時間: 2025-3-30 05:56
The Role of Mitochondria in the Activation/Maintenance of SOCE: Membrane Contact Sites as Signaling nsing STIM proteins on the endoplasmic reticulum (ER) and Ca.-permeable ORAI channels on the plasma membrane (PM). STIM-ORAI interactions occur at membrane contact sites (MCS), evolutionarily conserved cellular structures characterized by the close apposition (10–20 nm) between the ER and target mem作者: fulmination 時間: 2025-3-30 09:44 作者: CHANT 時間: 2025-3-30 13:07
Tissue Specificity: The Role of Organellar Membrane Nanojunctions in Smooth Muscle Ca2+ Signalingr transporters therein—to the cell signaling machinery, with specific reference to Ca. transport and signaling in vascular smooth muscle and endothelial cells. More specifically, we will consider the extent to which quantitative modeling may aid in the development of our understanding of these proce作者: 染色體 時間: 2025-3-30 17:07
James W. Putneyware Approach" steht im Mittelpunkt dieses Buches. Es hat zum Ziel, ein umfassendes Verst?ndnis der Rechnerfunktion und grundlegende Methoden des Rechnerentwurfs zu vermitteln, wobei von schaltungstechnischen, technologieabh?ngigen Fragestellungen abstrahiert wird. Dennoch ist durch eine ausgesproch作者: 賠償 時間: 2025-3-31 00:36 作者: 山頂可休息 時間: 2025-3-31 04:05
Aparna Gudlur,Patrick G. Hoganten von vielen Stunden) angegangen werden konnten, haben Computer mit einer neuen Architektur, sog. ., entscheidend beigetragen. Pioniere dieser Technik und erste Hersteller solcher Anlagen waren um die Mitte der siebziger Jahre zwei amerikanische Firmen, die Control Data Corporation (CDC) und Cray 作者: Heretical 時間: 2025-3-31 07:51 作者: 松軟無力 時間: 2025-3-31 10:02
in der die eigentliche Informationsverarbeitung und Systemsteuerung durchgeführt wird, einem Taktgeber und einem Bussystem. Prozessoren stellen dem Anwender einen Maschinencode zur Verfügung, der aus Bitfolgen besteht, die der Prozessor interpretiert, auswertet und danach entsprechende Operationen 作者: 不適 時間: 2025-3-31 15:16 作者: 陰郁 時間: 2025-3-31 19:07
