作者: optic-nerve 時間: 2025-3-21 22:41
A). RA is a chronic inflammatory disorder responsible for destruction of active and passive components of joints. It is the most common autoimmune disease, and the second most common form of arthritis after OA. OA is a chronic disorder characterized by irreversible changes in the joint structure dev作者: 不再流行 時間: 2025-3-22 00:35
Vytautas ?tuikys,Renata Burbait?ale for the development and evaluation of anti-angiogenic agents. To date bevacizumab, a monoclonal antibody directed against serum VEGF, is the only anti-angiogenic agent that has demonstrated improved overall survival for patients with lung cancer. Meta-analysis of trials of bevacizumab in combina作者: Onerous 時間: 2025-3-22 08:24 作者: 結(jié)合 時間: 2025-3-22 09:01 作者: 徹底明白 時間: 2025-3-22 15:28
currently available, this statistics is shocking. A possible explanation for the disconnect between sophisticated treatments and the survival rate can be related to the post-treatment enrichment of Cancer Stem Cells (CSCs), which is one of a sub-set of drug resistant tumor cells with abilities of se作者: 剛開始 時間: 2025-3-22 19:03 作者: 折磨 時間: 2025-3-23 00:50 作者: 間接 時間: 2025-3-23 02:20
n was pioneered by Reitz and colleagues and the first successful operation was carried out in 1981. Eventually, young patients were operated upon, who were generally adolescents with cystic fibrosis or the Eisenmenger syndrome. Successful single lung transplantation in adults with pulmonary fibrosis作者: Mendacious 時間: 2025-3-23 05:40 作者: 證明無罪 時間: 2025-3-23 10:34
Vytautas ?tuikys,Renata Burbait?ication used for idiopathic interstitial pneumonias has been applied to describe the histological patterns of RA-ILD, mixtures of these histological patterns, hyperplasia of bronchus-associated lymphoid tissue, and variable bronchiolar diseases complicate a pathological diagnosis. We investigated pa作者: urethritis 時間: 2025-3-23 16:19 作者: Nmda-Receptor 時間: 2025-3-23 19:43
Vytautas ?tuikys,Renata Burbait?g problem owing to the suppression of host immunity by these agents. Cellular immunity with T lymphocytes plays a crucial role in host defense against mycobacterial infections; hence, immunosuppression due to these biological agents may lead to tuberculosis (TB) and nontuberculous mycobacteria (NTM)作者: lambaste 時間: 2025-3-24 00:21
e disease that primarily affects joints. Recent advances in therapy for RA provide the benefit of achieving a better outcome in patients with arthritis, and a large number of reports on RA are now available. Moreover, the American College of Rheumatology and the European League Against Rheumatism ha作者: Analogy 時間: 2025-3-24 05:13 作者: 集合 時間: 2025-3-24 08:07
Vytautas ?tuikys,Renata Burbait?ssive and leads to substantial morbidity and mortality, highlighting the need for improved recognition of disease, including identification of targets for disease prevention and clinical tools that classify early stages of disease. Recent research has identified risk factors for both early-stage and作者: Asymptomatic 時間: 2025-3-24 13:49 作者: 空洞 時間: 2025-3-24 16:11
Vytautas ?tuikys,Renata Burbait?ight ventricular afterload and subsequent right ventricular heart failure. It is a condition which carries with it significant morbidity and mortality, and it can occur as a result of primary pulmonary arteriopathy or secondary to comorbid heart and lung diseases. Indoor and outdoor air pollution an作者: 箴言 時間: 2025-3-24 22:07
how clinicians can be aware and better determine environmental effects on lung health, and provides guidelines for medical providers to diagnose, counsel and mitigate risk. Various lung diseases are affected by the external environment. Asthma is common, however other airways diseases, such as inter作者: 高射炮 時間: 2025-3-25 02:15
Vytautas ?tuikys,Renata Burbait?ge the degree of a variety of functions, including contraction, proliferation, migration, and the secretion of inflammatory mediators (phenotype plasticity). Airflow limitation, airway hyperresponsiveness, β.-adrenergic desensitization, and airway remodeling, which are fundamental characteristic fea作者: covert 時間: 2025-3-25 04:55 作者: Polydipsia 時間: 2025-3-25 10:42
Understanding of Smart Content for STEM-Driven CS Educations functionality. The model . is the simplest. The model . specifies more functions but without the explicit use of STEM features. The model . implements explicit STEM attributes with enhanced functionality. The framework defines the understanding of these entities, using the following visions: learn作者: aphasia 時間: 2025-3-25 12:51
Model-Driven Design and Redesign of Smart STEM-Driven CS Contentake the horizontal transformation feasible, we define a vertical transformation on each left and right branches resulting on the decreasing level of abstraction to represent the models and sub-models so that it would be possible to apply the adequate transformation rules. At the top level, we repres作者: 思想 時間: 2025-3-25 16:22
Stage-Based Smart Learning Objects: Adaptation Perspectivee context-dependent selection of parameter values at each stage, enables the system to narrow the parameter space according to his/her context and, in this way, to adapt gradually the generated content. We analyse a case study, the stage-based adaptation processes and learning scenarios. Finally, we作者: 知識 時間: 2025-3-25 22:29
A Methodology and Tools for Creating Generative Scenario for STEMs meta-programming as generative technology. Structurally, the generative scenario is a system-level meta-program composed of a few meta-generators and generators. To our best knowledge, we have described the scenario specification based on using meta-programming techniques for the first time in the作者: 自傳 時間: 2025-3-26 00:45
Book 2018e and evaluate smart components from the pedagogical and technological perspectives based ondata gathered from one real teaching setting.?.Smart STEM-Driven Computer Science Education:.?.Theory, Methodology and Robot-based Practices.?outlines the overall capabilities of the proposed approach and als作者: expdient 時間: 2025-3-26 06:00 作者: 禍害隱伏 時間: 2025-3-26 12:24 作者: 不整齊 時間: 2025-3-26 13:39
g epithelial cell turnover. However, the low stem cell incorporation remains a problem. Pre-clinical studies imply that even 6–10?% of the wild-type cystic fibrosis transmembrane conductance regulator (CFTR) expression could be enough to restore chloride secretion. The route of administration, the o作者: Hippocampus 時間: 2025-3-26 18:03 作者: senile-dementia 時間: 2025-3-26 22:54
Vytautas ?tuikys,Renata Burbait?..Multiple oral anti-angiogenic compounds have been evaluated in NSCLC, both in first-line therapy, or upon disease progression. The majority of agents have shown some evidence of activity, but none have clearly demonstrated improvements in overall survival. Increased toxicities have been observed, 作者: 提升 時間: 2025-3-27 04:52 作者: 微不足道 時間: 2025-3-27 08:46
Vytautas ?tuikys,Renata Burbait?evaluated in SCLC and many studies of these strategies are on-going. Perhaps the most promising approaches involve agents targeting cancer stem cell pathways and immunomodulatory drugs that interfere with the PD1 and CTLA-4 pathways. SCLC offers many barriers to the development of successful therapy作者: 脆弱帶來 時間: 2025-3-27 13:12
ABCG2, and Nanog. Yet another cell type that is also associated with increased resistance to treatment is epithelial-to-mesenchymal transition (EMT) phenotypic cells. Through the processes of EMT, epithelial cells lose their epithelial phenotype and gain mesenchymal properties, rendering EMT phenoty作者: GOAT 時間: 2025-3-27 14:44
Vytautas ?tuikys,Renata Burbait?erable progress in understanding of the clinical behaviour of lung cancer thereby establishing the importance of distinguishing between the major histologic types. Thera- peutic advancement was particularly experienced in small cell carcinoma with the introduction of combination chemotherapy after t作者: CHOP 時間: 2025-3-27 21:33 作者: 課程 時間: 2025-3-27 22:07
Vytautas ?tuikys,Renata Burbait?blood vessels (i.e. arteries, arterioles, venules, and veins) from these initial vessels involves recruitment of smooth muscle cell (SMC) precursor cells into the region surrounding the endothelial tubes with subsequent morphogenesis of the appropriate blood vessel. This process requires that cells 作者: 手工藝品 時間: 2025-3-28 03:07
Vytautas ?tuikys,Renata Burbait?ar walls similar to the conditions observed in patients with emphysema and resulting in cystic changes in lobules were also seen in the lungs of patients with long-standing RA. The exact mechanism of peribronchiolar metaplasia with intralobular cystic alteration in the never smokers with RA still re作者: 陪審團 時間: 2025-3-28 10:10 作者: 昏暗 時間: 2025-3-28 13:51
Vytautas ?tuikys,Renata Burbait?sing diagnostic tools such as interferon-gamma release assay (IGRA), anti-MAC antibody measurement, and Xpert MTB/rifampin (RIF) assay are newly available. Further research is needed to verify these assays. As a rule, to avoid development of drug-resistant strains, treatment with multiple drugs for 作者: 充氣女 時間: 2025-3-28 16:29 作者: MUT 時間: 2025-3-28 20:06 作者: 古老 時間: 2025-3-29 02:08 作者: 草率男 時間: 2025-3-29 04:06 作者: 有角 時間: 2025-3-29 08:38 作者: 妨礙 時間: 2025-3-29 15:00
ion and occupational exposures, this resource explores newer areas of interest, including lung disease from recreational inhalants and the role of climate change on lung health. Written by expert respiratory specialists, the articles cover a wide range of topics, including:. ..How air pollution effe作者: 欄桿 時間: 2025-3-29 16:49 作者: 無能的人 時間: 2025-3-29 21:43
http://image.papertrans.cn/s/image/868945.jpg作者: osteopath 時間: 2025-3-30 01:11 作者: angina-pectoris 時間: 2025-3-30 04:56 作者: 男學(xué)院 時間: 2025-3-30 11:52 作者: PANG 時間: 2025-3-30 13:43 作者: 錯 時間: 2025-3-30 17:16
Book 2018riability, technological variability, CS content variability and interaction variability. To design smart components, firstly, the STEM learning variability space is defined for each component separately, and then model-driven approaches are applied. The theoretical basis includes feature-based mode作者: Trabeculoplasty 時間: 2025-3-30 23:36
