標(biāo)題: Titlebook: Sigma Receptors: Their Role in Disease and as Therapeutic Targets; Sylvia B. Smith,Tsung-Ping Su Book 2017 Springer International Publishi [打印本頁] 作者: CAP 時(shí)間: 2025-3-21 20:09
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書目名稱Sigma Receptors: Their Role in Disease and as Therapeutic Targets影響因子(影響力)學(xué)科排名
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書目名稱Sigma Receptors: Their Role in Disease and as Therapeutic Targets網(wǎng)絡(luò)公開度學(xué)科排名
書目名稱Sigma Receptors: Their Role in Disease and as Therapeutic Targets被引頻次
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書目名稱Sigma Receptors: Their Role in Disease and as Therapeutic Targets讀者反饋
書目名稱Sigma Receptors: Their Role in Disease and as Therapeutic Targets讀者反饋學(xué)科排名
作者: 沙漠 時(shí)間: 2025-3-21 21:54 作者: Mettle 時(shí)間: 2025-3-22 04:25 作者: FANG 時(shí)間: 2025-3-22 06:00 作者: 談判 時(shí)間: 2025-3-22 12:02
,The Evolution of the Sigma-2 (σ,) Receptor from Obscure Binding Site to , Therapeutic Target,o binding studies over 25 years ago, the molecular identity of this protein is currently not unambiguously known, and the results from recent attempts to identify the σ. receptor through protein purification and mass spectral analysis have been the subject of debate in the literature. However, there作者: 膠狀 時(shí)間: 2025-3-22 13:35 作者: 吃掉 時(shí)間: 2025-3-22 18:54 作者: 重力 時(shí)間: 2025-3-22 22:04
Pharmacological Modulation of the Sigma 1 Receptor and the Treatment of Pain,ies and reduce their unwanted effects. Current preclinical evidence supports the modulatory role of sigma-1 receptors (σ.R) in nociception, mainly based on the pain-attenuated phenotype of σ.R knockout mice and on the antinociceptive effect exerted by σ.R antagonists on pains of different etiologies作者: CODA 時(shí)間: 2025-3-23 02:13 作者: cuticle 時(shí)間: 2025-3-23 06:35
Sigma-1 Receptors and Neurodegenerative Diseases: Towards a Hypothesis of Sigma-1 Receptors as Ampldiseases. Accumulating evidence indicates that sigma-1 ligands can either directly or indirectly modulate multiple neurodegenerative processes, including excitotoxicity, calcium dysregulation, mitochondrial and endoplasmic reticulum dysfunction, inflammation, and astrogliosis. In addition, sigma-1 l作者: Phenothiazines 時(shí)間: 2025-3-23 09:47 作者: 手術(shù)刀 時(shí)間: 2025-3-23 14:10 作者: 興奮過度 時(shí)間: 2025-3-23 18:06
Sigma Receptors and Substance Use Disorders, of abuse, including alcohol, are able to produce significant neuroplastic changes responsible for the profound disturbances shown by drug addicted individuals. The current lack of efficacious pharmacological treatments for substance use disorders has encouraged the search for novel and more effecti作者: Coronary-Spasm 時(shí)間: 2025-3-24 00:33
Stimulation of the Sigma-1 Receptor and the Effects on Neurogenesis and Depressive Behaviors in Miculation antagonizes depressive-like behaviors in animal models, but molecular mechanisms underlying this effect remain unclear. Here, we focus on the effects of Sig-1R ligands on hippocampal neurogenesis and depressive-like behaviors. Sig-1R stimulation also enhances CaMKII/CaMKIV and protein kinase作者: 事先無準(zhǔn)備 時(shí)間: 2025-3-24 04:41
,Role of σ1 Receptors in Learning and Memory and Alzheimer’s Disease-Type Dementia,nists have been tested in a variety of pharmacological and pathological models of learning impairments in rodents these last past 20 years. Their anti-amnesic effects have been explained by the wide-range modulatory role of σ. receptors on Ca. mobilizations, neurotransmitter responses, and particula作者: 手銬 時(shí)間: 2025-3-24 08:32
Sigma-1 Receptor in Motoneuron Disease,Multiple etiopathogenic mechanisms appear to contribute in the development of ALS, including glutamate excitotoxicity, oxidative stress, protein misfolding, mitochondrial defects, impaired axonal transport, inflammation and glial cell alterations. The Sigma-1 receptor is highly expressed in motoneur作者: 牌帶來 時(shí)間: 2025-3-24 12:10
,The Sigma-1 Receptor–A Therapeutic Target for the Treatment of ALS?,ord motor neuron activation occurs, in part, via large ventral horn cholinergic synapses called C-boutons/C-terminals. Chronic excitation of motor neurons and alterations in C-terminals has been associated with Amyotrophic Lateral Sclerosis (ALS). The S1R has an important role in regulating motor ne作者: municipality 時(shí)間: 2025-3-24 15:41
The Role of Sigma1R in Mammalian Retina,performed in the late 1990s that provided evidence of the presence of Sigma1R in various ocular tissues. It then describes work from a number of labs concerning the location of Sigma1R in several retinal cell types including ganglion, Müller glia, and photoreceptors. The role of Sigma1R ligands in r作者: 單片眼鏡 時(shí)間: 2025-3-24 19:38
Peeking into Sigma-1 Receptor Functions Through the Retina,vorable experimental model system. The exquisite architecture of the mammalian retina features layered and intricately wired neurons supported by non-neuronal cells. Ganglion neurons, photoreceptors, as well as the retinal pigment epithelium, are susceptible to degeneration that leads to major retin作者: 忘恩負(fù)義的人 時(shí)間: 2025-3-25 00:27
Book 2017ny degenerative diseases with remarkable?potential as therapeutic targets. In this text, new information about the structure of sigma 1 receptor, its binding sites are provided as well as its expression in many cell types.? It’s putative role in degenerative neuronal diseases including amyotrophic l作者: 碳水化合物 時(shí)間: 2025-3-25 04:32
Book 2017 treatments for blinding retinal diseases emphasize the tremendous far-reaching potential for ligands for these receptors.? Exciting breakthroughs in this dynamic field in the last decade are reported herein, which will guide future investigators in determining the full potential of this unique, yet abundantly expressed protein..作者: 悠然 時(shí)間: 2025-3-25 07:55 作者: 確定無疑 時(shí)間: 2025-3-25 12:55
Structural Perspectives on Sigma-1 Receptor Function,each protomer binds a single ligand molecule at the center of its carboxy-terminal domain. These results offer detailed molecular views of receptor structure, oligomerization, and ligand recognition, providing a framework for the next era of sigma-1 research.作者: 把…比做 時(shí)間: 2025-3-25 16:52 作者: AROMA 時(shí)間: 2025-3-25 20:56 作者: GEST 時(shí)間: 2025-3-26 03:54 作者: 含糊其辭 時(shí)間: 2025-3-26 06:33
Sigma Receptors and Substance Use Disorders, including cocaine, methamphetamine, and alcohol. The present chapter will review the current scientific knowledge on the role of the Sigma Receptor system in the effects of drugs and alcohol, and proposes that this receptor system may represent a novel therapeutic target for the treatment of substance use disorders and associated neurotoxicity.作者: Conquest 時(shí)間: 2025-3-26 08:45
0065-2598 f significant relevance to very severe diseases (blindness, .Originally confused with opioid receptors and then orphan receptors with no biological function, Sigma Receptors are now recognized as relevant to many degenerative diseases with remarkable?potential as therapeutic targets. In this text, n作者: 我不怕犧牲 時(shí)間: 2025-3-26 15:04 作者: acheon 時(shí)間: 2025-3-26 18:18
Stimulation of the Sigma-1 Receptor and the Effects on Neurogenesis and Depressive Behaviors in Mic B (Akt) activities in hippocampus. Therefore, we discuss the fundamental roles of Sig-1R, CaMKII/CaMKIV and protein kinase B (Akt) signaling in amelioration of depressive-like behaviors following Sig-1R stimulation.作者: 顯示 時(shí)間: 2025-3-27 00:58
Sylvia B. Smith,Tsung-Ping SuVery few books about Sigma receptors, yet the field regarding Sigma receptors has exploded.A comprehensive treatise on this unique protein.Of significant relevance to very severe diseases (blindness, 作者: carotid-bruit 時(shí)間: 2025-3-27 04:19 作者: 槍支 時(shí)間: 2025-3-27 08:57 作者: 菊花 時(shí)間: 2025-3-27 11:34 作者: 空中 時(shí)間: 2025-3-27 14:37
https://doi.org/10.1007/978-3-319-50174-1Drug Target; Molecular Chaperone; Neurodegeneration; Neuroprotection; Sigma 1 Receptor; Receptors作者: 警告 時(shí)間: 2025-3-27 18:44
Manuel Merlos,Javier Burgue?o,Enrique Portillo-Salido,Carlos Ramón Plata-Salamán,José Miguel Vela作者: 有害 時(shí)間: 2025-3-27 22:23
Cristina Sánchez-Fernández,José Manuel Entrena,José Manuel Baeyens,Enrique José Cobos作者: CLAN 時(shí)間: 2025-3-28 04:25 作者: 激怒 時(shí)間: 2025-3-28 09:00 作者: 斗志 時(shí)間: 2025-3-28 13:08 作者: 煩憂 時(shí)間: 2025-3-28 18:21 作者: CURT 時(shí)間: 2025-3-28 20:25 作者: Terminal 時(shí)間: 2025-3-29 02:01 作者: 遺傳 時(shí)間: 2025-3-29 06:58
Frauke Weber,Peter Brust,Erik Laurini,Sabrina Pricl,Bernhard Wünschand economic opportunity, it is an important part of the management of social change and has inherent potential for influencing the course of future social change. Conceptually, however, the compensation problem involves much more than intentional redistribution. The argument of this Article is: (1)作者: 自愛 時(shí)間: 2025-3-29 09:04
Chenbo Zeng,Robert H. Mach the findings of a recent study. in which social indicators on court performance were constructed to measure how Michigan District Courts are performing under current methods of court financing and judicial compensation and selection, and what citizens can expect from a change to state-wide district作者: 寒冷 時(shí)間: 2025-3-29 12:50 作者: facetious 時(shí)間: 2025-3-29 18:55 作者: Explicate 時(shí)間: 2025-3-29 22:44
Valentina Sabino Ph.D.,Callum Hicks Ph.D.,Pietro Cottone Ph.D.tion, resulted from internal factors. As Grechenig and Gelter convincingly explain, at the beginning of the movement in the nineteenth and the early twentieth century the developments were comparable in Europe and the USA. The Nazi regime and World War II then marked a turning point, which resulted 作者: AGATE 時(shí)間: 2025-3-30 03:41
Kohji Fukunaga,Shigeki Moriguchier moralism, with an analogical and practical reasoning rather than abstract reasoning, with an inductive rather than an deductive approach – in short, these principles are founded with pragmatism rather than with legalism..Indeed, the analysis of the general principles of EU law understood in their作者: Paradox 時(shí)間: 2025-3-30 05:04 作者: 保存 時(shí)間: 2025-3-30 09:57
Renzo Mancuso,Xavier Navarroally, the fourth part focuses on the role economic analysis plays in the law of the European Union. This anthology with its 14 essays from young European legal scholars is an important milestone in establishing a European law and economics culture and tradition.978-94-024-0596-5978-94-007-7110-9Series ISSN 2512-1294 Series E-ISSN 2512-1308 作者: INERT 時(shí)間: 2025-3-30 12:23 作者: Texture 時(shí)間: 2025-3-30 18:57
Jing Wang,Xuezhi Cui,Penny Roon,Alan Saul,Sylvia B. Smith Ph.D.tion, resulted from internal factors. As Grechenig and Gelter convincingly explain, at the beginning of the movement in the nineteenth and the early twentieth century the developments were comparable in Europe and the USA. The Nazi regime and World War II then marked a turning point, which resulted 作者: 陳列 時(shí)間: 2025-3-30 23:32
Timur A. Mavlyutov,Lian-Wang Guohree case studies to very different regulatory networks, the Body of European Regulators for Electronic Communication (BEREC), the European Competition Network (ECN), and the International Competition Network (ICN). An important result is that regulatory networks might not only be a temporary phenom作者: aggressor 時(shí)間: 2025-3-31 01:46 作者: Vsd168 時(shí)間: 2025-3-31 08:27 作者: Hiatal-Hernia 時(shí)間: 2025-3-31 11:55
Sigma-1 Receptor Antagonists: A New Class of Neuromodulatory Analgesics,an increase in opioid side effects, including tolerance, dependence or constipation, so the use of sigma-1 antagonists may increase the therapeutic index of opioids. Furthermore, sigma-1 antagonists (in the absence of opioids) have been shown to exert antinociceptive effects in preclinical models of作者: Allodynia 時(shí)間: 2025-3-31 14:15
Sigma-1 Receptors and Neurodegenerative Diseases: Towards a Hypothesis of Sigma-1 Receptors as Amplction worsens disease progression, whereas enhancement amplifies pre-existing functional mechanisms of neuroprotection and/or restoration to slow disease progression. Collectively, the data support a model of the sigma-1 receptor as an amplifier of intracellular signaling, and suggest future clinica作者: 比目魚 時(shí)間: 2025-3-31 18:37 作者: rods366 時(shí)間: 2025-4-1 01:15 作者: Entropion 時(shí)間: 2025-4-1 05:11 作者: SNEER 時(shí)間: 2025-4-1 07:28
Sigma-1 Receptor in Motoneuron Disease,e neuroprotection and neurite elongation through activation of protein kinase C on motoneurons in vitro and in vivo after ventral root avulsion. Remarkably, treatment of SOD1 mice, the most usual animal model of ALS, with Sigma-1R agonists resulted in significantly enhanced motoneuron function and p作者: implore 時(shí)間: 2025-4-1 13:30 作者: MUTE 時(shí)間: 2025-4-1 16:23 作者: 夾死提手勢 時(shí)間: 2025-4-1 20:50
Peeking into Sigma-1 Receptor Functions Through the Retina,d by in vitro and in vivo experiments. Most recently, studies suggest that S1R may also protect retinal neurons via its activities in Müller glia and microglia. The S1R functions in the retina may be attributed to a reduction of excitotoxicity, oxidative stress, ER stress response, or inflammation.
