標(biāo)題: Titlebook: Serpins; Methods and Protocol Alexandra Lucas Book 2018 Springer Science+Business Media, LLC, part of Springer Nature 2018 Serine protease [打印本頁] 作者: 法庭 時間: 2025-3-21 19:55
書目名稱Serpins影響因子(影響力)
書目名稱Serpins影響因子(影響力)學(xué)科排名
書目名稱Serpins網(wǎng)絡(luò)公開度
書目名稱Serpins網(wǎng)絡(luò)公開度學(xué)科排名
書目名稱Serpins被引頻次
書目名稱Serpins被引頻次學(xué)科排名
書目名稱Serpins年度引用
書目名稱Serpins年度引用學(xué)科排名
書目名稱Serpins讀者反饋
書目名稱Serpins讀者反饋學(xué)科排名
作者: 緩和 時間: 2025-3-21 23:38 作者: expire 時間: 2025-3-22 00:26
Methods in Molecular Biologyhttp://image.papertrans.cn/s/image/865499.jpg作者: 低能兒 時間: 2025-3-22 08:01 作者: 油氈 時間: 2025-3-22 12:42
Alexandra LucasIncludes cutting-edge methods and protocols.Provides step-by-step detail essential for reproducible results.Contains key notes and implementation advice from the experts作者: 協(xié)奏曲 時間: 2025-3-22 16:17 作者: 名次后綴 時間: 2025-3-22 19:23
Cellular Models for the Serpinopathies,have been extensively modeled in cell culture systems by expressing mutant variants in a variety of ways. Here we describe the methodologies we follow in our cell model systems used to examine serpin disorders.作者: Pudendal-Nerve 時間: 2025-3-22 22:13
Viral Serpin Reactive Center Loop (RCL) Peptides: Design and Testing,sert their RCL into adjacent serpins forming aggregates of inactive serpins..We have further posited that this natural cleavage site in the serpin RCL may form active serpin metabolites with potential to add to the serpin’s inhibitory functions. We have developed RCL peptides based upon predicted se作者: 摘要 時間: 2025-3-23 04:16 作者: 發(fā)芽 時間: 2025-3-23 09:35 作者: Blemish 時間: 2025-3-23 13:15
Serpins: Development for Therapeutic Applications,s a therapeutic or through blockade of serpins that are detrimental. Several drugs have been developed and are currently in use and/or in development both to replace dysfunctional serpins and to block adverse effects induced by aberrant protease or serpin actions..With this chapter, we provide a gen作者: 最初 時間: 2025-3-23 14:10
1064-3745 rpins: Methods and Protocols. is a valuable resource for researchers and scientists interested in learning more about this evolving field..978-1-4939-9352-9978-1-4939-8645-3Series ISSN 1064-3745 Series E-ISSN 1940-6029 作者: 羽毛長成 時間: 2025-3-23 19:19 作者: 圍裙 時間: 2025-3-24 02:10 作者: 朝圣者 時間: 2025-3-24 03:21
Brian P. Mahon,Robert McKennaty of K?nigsberg. K?nigsberg was by no means the most distinguished of the German universities, but Kant found sufficient contentment there to make this university his academic home for the remainder of his life. After a period of private tutoring, during which he refused an offer from the Universit作者: dragon 時間: 2025-3-24 08:39
Lucas R. de Souza,Benjamin M. Scott,Varsha Bhakta,David A. Donkor,Darian L. Perruzza,William P. Shef Hilfskraft tatkr?ftig bei der Durchführung der praktischen Arbeiten halfen. Ein besonderer Dank gilt meiner lieben Frau, die die orthographische und syntakti- sche Durchsicht der Arbeit übernahm und mir viele private Arbeiten abnahm, sowie meiner gesamten Familie, die w?hrend der Arbeit oft auf mich verzicht978-3-528-06386-3978-3-663-06841-9作者: 和平主義 時間: 2025-3-24 14:32 作者: offense 時間: 2025-3-24 14:58
Masmudur M. Rahmant tatkr?ftig bei der Durchführung der praktischen Arbeiten halfen. Ein besonderer Dank gilt meiner lieben Frau, die die orthographische und syntakti- sche Durchsicht der Arbeit übernahm und mir viele private Arbeiten abnahm, sowie meiner gesamten Familie, die w?hrend der Arbeit oft auf mich verzicht作者: 牌帶來 時間: 2025-3-24 21:34 作者: 鉆孔 時間: 2025-3-25 01:09
Liqiang Zhang,Jordan R. Yaron,Sriram Ambadapadi,Alexandra Lucasls, Judith Jarvis Thomson, and Derek Parfit—to analyze?.Uncle Tom’s Children., especially “Down by the Riverside,” alongside other works by Wright. This approach emphasizes Wright’s recognition of the importance and integrity of Kant’s concept of dignity.978-3-031-40218-0978-3-031-40216-6Series ISSN 2634-579X Series E-ISSN 2634-5803 作者: degradation 時間: 2025-3-25 05:34
Sihong Song,Yuanqing Lu,Ahmed S. Elshikhate these roles; the demands it makes of parents, for instance, are different from those it makes of employers because the relationship between parents and children is different from that of employers and workers. Much of the chapter is dedicated to exploring these differences.作者: Unsaturated-Fat 時間: 2025-3-25 07:55
Hao Chen,Sriram Ambadapadi,Erbin Dai,Liying Liu,Jordan R. Yaron,Liqiang Zhang,Alexandra Lucasonomy via legislation is explored, we do not advocate this as the only means by which the attention economy should be checked. In this chapter and others, we emphasize the important role that culture and education can and should play in restructuring our relationship with our devices.作者: Reverie 時間: 2025-3-25 13:00 作者: MELON 時間: 2025-3-25 16:04
Juan Maldonado,Jordan R. Yaron,Liqiang Zhang,Alexandra Lucase issues of using animals as mere means, the ethics of veganism and vegetarianism, and environmental protection. Nico Dario Müller shows how, when furnished with duties to animals, Kant‘s moral philosophy can be a powerful resource for animal ethicists.?.978-3-031-01932-6978-3-031-01930-2Series ISSN 2634-6672 Series E-ISSN 2634-6680 作者: LIKEN 時間: 2025-3-25 22:46 作者: Magnitude 時間: 2025-3-26 03:22
Cristhian J. Ildefonso,Alfred S. Lewine issues of using animals as mere means, the ethics of veganism and vegetarianism, and environmental protection. Nico Dario Müller shows how, when furnished with duties to animals, Kant‘s moral philosophy can be a powerful resource for animal ethicists.?.978-3-031-01932-6978-3-031-01930-2Series ISSN 2634-6672 Series E-ISSN 2634-6680 作者: conjunctivitis 時間: 2025-3-26 04:22 作者: 護航艦 時間: 2025-3-26 09:00 作者: 忍受 時間: 2025-3-26 12:51
Sihong Song,Yuanqing Luarious challenges to both conceptualist and nonconceptualist interpretations of Kant. Two further chapters explore a prominent Hegelian conceptualist reading of Kant and Kant’s nonconceptualist position in the 978-1-349-71022-5978-1-137-53517-7作者: Estimable 時間: 2025-3-26 18:10
Emma L. K. Elliston,David A. Lomas,James A. Irving作者: affluent 時間: 2025-3-27 00:46
Annamaria Fra,Emanuela D’Acunto,Mattia Laffranchi,Elena Miranda作者: impale 時間: 2025-3-27 01:13 作者: 沉默 時間: 2025-3-27 07:15
Overview of Serpins and Their Roles in Biological Systems,resent in all kingdoms and often regulating central pathways for clotting, immunity, and even cancer in man. Serpins have been present from the time of the dinosaurs and can represent a large proportion of circulating blood proteins. With this introductory chapter, we present an overview of serpins 作者: Rotator-Cuff 時間: 2025-3-27 10:59
Methods for Determining and Understanding Serpin Structure and Function: X-Ray Crystallography,n and inhibitory mechanisms. In addition, high-resolution structural information of serpins derived from the three domains of life (bacteria, archaea, and eukaryotic) and viruses has provided valuable insights into the hereditary and evolutionary history of this unique superfamily of proteins. This 作者: 保守黨 時間: 2025-3-27 16:13 作者: intricacy 時間: 2025-3-27 18:50 作者: anchor 時間: 2025-3-28 00:01
Methods for Identifying Virus-Derived Serpins,ce of mammalian proteases to facilitate virus replication in the infected host. DNA viruses, in particular members of the poxvirus family, have acquired multiple copies of the functional serpins which are essential for viral pathogenesis. Virus-encoded serpins have proven to be very effective inhibi作者: PARA 時間: 2025-3-28 04:48 作者: 內(nèi)閣 時間: 2025-3-28 09:51 作者: Tempor 時間: 2025-3-28 14:00
Binding of Serpins to Immobilized Phospholipids and Phospholipids in Suspension,itory activity and—at least in the case of SERPINA5—to mediate serpin internalization into cells. Also phospholipid functions may be altered when bound to serpins or other proteins..By interacting with phospholipids, serpins might influence a variety of cellular functions. Binding of proteins to pho作者: sperse 時間: 2025-3-28 18:20
Viral Serpin Reactive Center Loop (RCL) Peptides: Design and Testing,aves the RCL, the serpin and protease become covalently linked leading to a loss of function of both the protease and the serpin; this suicide inhibition is often referred to as a “mouse trap.” When the RCL P1-P1′ scissile bond is cut by the protease, the resulting bond between the protease and the 作者: 骨 時間: 2025-3-28 20:51 作者: 輕信 時間: 2025-3-29 02:16 作者: tendinitis 時間: 2025-3-29 07:03 作者: 悲痛 時間: 2025-3-29 08:39 作者: AVOW 時間: 2025-3-29 14:15 作者: negotiable 時間: 2025-3-29 15:50
Methods for Assessing Serpins as Neuroprotective Therapeutics,ordinarily protracted, destructive inflammation follows the initial injury. Appropriate anti-inflammatory therapies of sufficient duration should not only inhibit but also lead to the elimination of this destructive inflammation, thus resulting in neuroprotection of the spinal cord tissue and a grea作者: 免除責(zé)任 時間: 2025-3-29 20:56
Adeno-Associated Virus Delivery of Viral Serpins for Ocular Diseases: Design and Validation,inical trials. This viral vector has a 4.7?kbp (kilo base pair) carrying capacity (single-stranded DNA) and only retains the inverted terminal repeats (ITRs) from the original virus. Here we describe the design and testing of AAV vectors capable of delivering an anti-inflammatory .ine .rotease .hibi作者: ingestion 時間: 2025-3-30 01:41
Serpins: Development for Therapeutic Applications,n and breakdown, immune responses, lung function, and hormone or central nervous system activity, among many others. When serine protease activity or serpin-mediated regulation becomes unbalanced or dysfunctional, then severe disease states and pathogenesis can ensue. With serpinopathies, genetic mu作者: 流動才波動 時間: 2025-3-30 08:04 作者: 遺棄 時間: 2025-3-30 08:23
Serpin Phage Display: The Use of a T7 System to Probe Reactive Center Loop Libraries with Differentibits. In this chapter, we describe protocols to assess the feasibility of this method for different serpin/proteinase combinations and share experience with this technology gathered in the course of studying two serpins and multiple proteinases with this powerful iterative screening approach.作者: 富足女人 時間: 2025-3-30 14:58
Kinetic Measurement of Serpin Inhibitory Activity by Real-Time Fluorogenic Biochemical Assay,ds covered include measurement of alpha-1-antitrypsin inhibitory activity against trypsin and heparin-dependent anti-thrombin III inhibitory activity against thrombin. These methods are scalable to small-volume, high-density format and can be applied for high-throughput screening of serpin activity modulators.作者: 群島 時間: 2025-3-30 19:01 作者: Common-Migraine 時間: 2025-3-30 21:36 作者: 騙子 時間: 2025-3-31 04:43 作者: Debrief 時間: 2025-3-31 09:06
Adeno-Associated Virus Delivery of Viral Serpins for Ocular Diseases: Design and Validation, as therapeutic stand-alone immune-modulating proteins for inflammation-based disorders and the myxoma virus itself is under development as a viral oncolytic platform for cancer treatment. We fused the Serp2 gene with the GFP reporter gene through a self-cleaving peptide.作者: condemn 時間: 2025-3-31 09:26
1064-3745 ation advice from the expertsThis volume explores the latest methods used to study and define serpin molecular structure, basic protease inhibition, serpin targets, and the roles of serpin in biology and disease using animal models. The chapters in this book cover topics such as crystallography and 作者: compose 時間: 2025-3-31 16:01 作者: Arroyo 時間: 2025-3-31 18:35
Book 2018ucible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls..Cutting edge and authoritative, .Serpins: Methods and Protocols. is a valuable resource for researchers and scientists interested in learning more about this evolving field..作者: 突變 時間: 2025-4-1 00:31
Methods for Determining and Understanding Serpin Structure and Function: X-Ray Crystallography,l applications to serpin structural biology will be briefly discussed. As serpins remain important both biologically and medicinally, the information provided in this chapter will aid in future experiments to expand our knowledge of this family of proteins.作者: Osteoarthritis 時間: 2025-4-1 02:39
In Vivo Analysis of Alpha-1-Antitrypsin Functions in Autoimmune Disease Models,therapy has also been tested and has demonstrated protective effects in a collagen-induced arthritis model and a systemic lupus erythematosus (SLE) mouse model. This chapter describes methods that evaluate AAT functions in autoimmune mouse models.
