標(biāo)題: Titlebook: Research in Computational Molecular Biology; 16th Annual Internat Benny Chor Conference proceedings 2012 Springer-Verlag Berlin Heidelberg [打印本頁(yè)] 作者: architect 時(shí)間: 2025-3-21 18:31
書(shū)目名稱Research in Computational Molecular Biology影響因子(影響力)
書(shū)目名稱Research in Computational Molecular Biology影響因子(影響力)學(xué)科排名
書(shū)目名稱Research in Computational Molecular Biology網(wǎng)絡(luò)公開(kāi)度
書(shū)目名稱Research in Computational Molecular Biology網(wǎng)絡(luò)公開(kāi)度學(xué)科排名
書(shū)目名稱Research in Computational Molecular Biology被引頻次
書(shū)目名稱Research in Computational Molecular Biology被引頻次學(xué)科排名
書(shū)目名稱Research in Computational Molecular Biology年度引用
書(shū)目名稱Research in Computational Molecular Biology年度引用學(xué)科排名
書(shū)目名稱Research in Computational Molecular Biology讀者反饋
書(shū)目名稱Research in Computational Molecular Biology讀者反饋學(xué)科排名
作者: 搖曳 時(shí)間: 2025-3-21 22:54 作者: 排名真古怪 時(shí)間: 2025-3-22 01:21
Sivan Bercovici,Jesse M. Rodriguez,Megan Elmore,Serafim Batzoglouy. Different recombinant (r) AAV vectors have been generated which seem to have some advantages in comparison with other vectors, like the ability to transduce terminally differentiated and non-dividing cells, the lack of any apparent pathogenicity, a low immunogenicity, a relatively high stability 作者: 煩擾 時(shí)間: 2025-3-22 06:39
Stefan Canzar,Mohammed El-Kebir,René Pool,Khaled Elbassioni,Alpesh K. Malde,Alan E. Mark,Daan P. Geen gene transfer methods has allowed for development of gene therapy protocols for the treatment of diverse types of diseases, including metabolic, cardiovas- lar, and autoimmune diseases, as well as cancer. For example, clinical trials for gene therapy of cancer, cystic fibrosis, ADA deficiency, and作者: Incompetent 時(shí)間: 2025-3-22 12:19 作者: 袖章 時(shí)間: 2025-3-22 13:12
Dan F. DeBlasio,Travis J. Wheeler,John D. Kececiogluproximately 1 month, and then decline to trace levels that persist for 1 year or more (.,.). However, even during the first month, transgene expression levels are too variable and too low to provide consistent therapeutic levels of circulating proteins. Thus, most intramuscular plasmid-based gene th作者: 自戀 時(shí)間: 2025-3-22 20:36 作者: 使出神 時(shí)間: 2025-3-22 21:34
Melissa Gymrek,David Golan,Saharon Rosset,Yaniv Erlich0 years. However, Japan shows a remarkable delay compared with the West in the clinical application of gene therapy, and one reason is that organizations manufacturing bioproducts for conducting high-quality clinical studies have not been fully established in Japan. Recently, the Japanese government作者: 卡死偷電 時(shí)間: 2025-3-23 02:56
Dan He,Buhm Han,Eleazar Eskinlated BMCs produce collagenases including matrix metalloproteinase-9. As a result, we observed reduced liver fibrosis, elevated serum albumin levels, and a significant increase in survival. Based on these data, we have begun “autologous bone marrow cell infusion (ABM.) therapy” using non-cultured au作者: HACK 時(shí)間: 2025-3-23 06:58
Lu He,Fabio Vandin,Gopal Pandurangan,Chris Bailey-Kelloggn its cells. Conventional therapeutic methods are often insufficient or unavailable to manage genetic diseases in the liver; therefore, more efficient strategies are urgently needed. Gene therapy emerged as novel method of treatment relying on liver-directed transfer of a gene-coding sequence to pro作者: 沉思的魚(yú) 時(shí)間: 2025-3-23 13:23 作者: 悠然 時(shí)間: 2025-3-23 16:27 作者: THROB 時(shí)間: 2025-3-23 19:35
Yan Huang,Yin Hu,Corbin D. Jones,James N. MacLeod,Derek Y. Chiang,Yufeng Liu,Jan F. Prins,Jinze Liune expression in a?variety of tissues such as muscle, eye, brain, liver, and lung?[. . . . . . .]. As the significance of AAV as a?gene therapy vector has been realized over the past years, recent developments in recombinant AAV (rAAV) production and purification have revolutionized the AAV field. I作者: Morphine 時(shí)間: 2025-3-23 22:25
Marcus Kinsella,Vineet Bafnane expression in a?variety of tissues such as muscle, eye, brain, liver, and lung?[. . . . . . .]. As the significance of AAV as a?gene therapy vector has been realized over the past years, recent developments in recombinant AAV (rAAV) production and purification have revolutionized the AAV field. I作者: Aggressive 時(shí)間: 2025-3-24 03:36
Yang Li,Hong-Mei Li,Paul Burns,Mark Borodovsky,Gene E. Robinson,Jian Malusively, or stealthing the vector against nonspecific interactions with host cells and proteins. These approaches offer the potential advantages of enhanced therapeutic effects, reduced side effects, lowered dosages, and enhanced therapeutic economics. This review will discuss a?variety of targetin作者: ingenue 時(shí)間: 2025-3-24 09:18
Yaw-Ling Lin,Charles Ward,Steven Skienainal feature. Evidence of this debilitating disorder dates back to 1000 B.C. Skeletons of mummies from this period reveal abnormal growth patterns similar to those of OI patients. Ivar the Boneless, the Danish prince who led the Scandinavian invasion of England, was believed to have such severe OI t作者: Introvert 時(shí)間: 2025-3-24 10:45
Marc A. Marti-Renomre divided into 2 types: a shearing injury, in which both the myofibers and the connective tissue framework are torn, or an in situ injury, in which only the myofibers are damaged and the basal lamina and connective tissue sheaths do not undergo significant harm. Shearing injuries, the most frequent作者: 異端 時(shí)間: 2025-3-24 16:21
Andrew McPherson,Chunxiao Wu,Alexander Wyatt,Sohrab Shah,Colin Collins,S. Cenk Sahinalpnd important phase of medical progress was the discovery of vaccination, which not only led to an understanding of the complexity of the immune response, but also to a systematic method of treating a variety of transmissible diseases. The third important step in the development of medicine was the t作者: Insatiable 時(shí)間: 2025-3-24 19:12 作者: headlong 時(shí)間: 2025-3-24 23:15
Andrew S. Parker,Karl E. Griswold,Chris Bailey-Kelloggents in novel receptor/liposome-based transfection systems have made nonviral gene therapy a real possibility. Described here is a novel, high-efficiency, nonviral protocol for delivery of genes into permeabilized primary cultured cells forming a first step toward ex vivo gene therapy for the repair作者: agglomerate 時(shí)間: 2025-3-25 04:18
0302-9743 l International Conference on Research in Computational Molecular Biology, RECOMB 2012, held in Barcelona, Spain, in April 2012. The 31 revised full papers presented together with 5 keynote lectures were carefully reviewed and selected from 200 submissions. The papers feature current research in all作者: 姑姑在炫耀 時(shí)間: 2025-3-25 09:10 作者: adipose-tissue 時(shí)間: 2025-3-25 14:35
Ancestry Inference in Complex Admixtures via Variable-Length Markov Chain Linkage Models,Markov chain. We test ALLOY in a broad range of scenarios ranging from recent to ancient admixtures with up to four ancestral populations. We show that ALLOY outperforms the previous state of the art, and is robust to uncertainties in model parameters.作者: 混合 時(shí)間: 2025-3-25 15:57 作者: infelicitous 時(shí)間: 2025-3-25 23:48 作者: 我不明白 時(shí)間: 2025-3-26 00:37 作者: 安心地散步 時(shí)間: 2025-3-26 05:23
The Three-Dimensional Architecture of a Bacterial Genome and Its Alteration by Genetic Perturbationt genes. Such rotations did not lead to large-scale changes in gene expression, indicating that genome folding does not strongly affect gene regulation. Collectively, our data suggest that genome folding is globally dictated by the .S sites and chromosome segregation. Highlight of an article published in Molecular Cell in 2011.作者: genesis 時(shí)間: 2025-3-26 11:51
Modeling the Breakage-Fusion-Bridge Mechanism: Combinatorics and Cancer Genomics,ns. We find that a sequence of BFB operations can be found that nearly fits most patterns of copy number increases along a chromosome. We conclude that this limits the usefulness of methods like array CGH for detecting BFB and discuss other implications for understanding mechanisms of genomic instability.作者: 煩人 時(shí)間: 2025-3-26 16:26 作者: BUST 時(shí)間: 2025-3-26 17:12 作者: 量被毀壞 時(shí)間: 2025-3-27 00:43
TrueSight: Self-training Algorithm for Splice Junction Detection Using RNA-seq,led TrueSight, that combines information from (i) RNA-seq read mapping quality and (ii) coding potential from the reference genome sequences into a unified model that utilizes semi-supervised learning to precisely identify splice junctions.作者: assent 時(shí)間: 2025-3-27 03:17 作者: 壓倒性勝利 時(shí)間: 2025-3-27 06:00
Protein Structure by Semidefinite Facial Reduction,ve of these methods is to minimize the error of deviating from the NOE distance constraints. However, this objective function is highly nonconvex and, consequently, difficult to optimize. Euclidean distance geometry methods based on semidefinite programming (SDP) provide a natural formulation for th作者: 熱心助人 時(shí)間: 2025-3-27 10:00 作者: 人充滿活力 時(shí)間: 2025-3-27 15:19
Charge Group Partitioning in Biomolecular Simulation, fields to represent the intermolecular interactions. There are many different force fields available|each based on a different set of assumptions and thus requiring different parametrization procedures. Recently, efforts have been made to fully automate the assignment of force-field parameters, inc作者: 偽證 時(shí)間: 2025-3-27 18:32
Increased Methylation Variation in Epigenetic Domains across Cancer Types,ed regions (cDMRs) in colon cancer, which also distinguish normal tissue types from each other, suggesting that these cDMRs might be generalized across cancer types. Here we show stochastic methylation variation of the same cDMRs, distinguishing cancer from normal tissue, in colon, lung, breast, thy作者: obtuse 時(shí)間: 2025-3-28 00:25
Estimating the Accuracy of Multiple Alignments and its Use in Parameter Advising, and use our approach to address a new problem that we call .. For protein alignments, we consider twelve independent features that contribute to a quality alignment. An accuracy estimator is learned that is a polynomial function of these features; its coefficients are determined by minimizing its e作者: Offbeat 時(shí)間: 2025-3-28 04:57
Quantifying the Dynamics of Coupled Networks of Switches and Oscillators,components (represented as nodes) in networks. For example, models of coupled switches have been applied to model systems such as neuronal synapses and gene regulatory networks. Similarly, models of coupled oscillators along networks have been used to model synchronization of oscillators which has b作者: 輕快走過(guò) 時(shí)間: 2025-3-28 06:17
lobSTR: A Short Tandem Repeat Profiler for Personal Genomes,es that comprise hundreds of thousands of loci in the human genome. The repetitive structure of these loci makes them prone to replication slippage events [5] that can reach a rate of 1/500 mutations per locus per generation [8], 200,000 fold higher than the rate of . single nucleotide polymorphims 作者: 無(wú)關(guān)緊要 時(shí)間: 2025-3-28 13:40 作者: 無(wú)表情 時(shí)間: 2025-3-28 17:08 作者: 假裝是你 時(shí)間: 2025-3-28 19:31 作者: abolish 時(shí)間: 2025-3-29 00:00
,LoopWeaver – Loop Modeling by the Weighted Scaling of Verified Proteins,niques have the advantage of producing a higher proportion of predictions with sub-angstrom accuracy, when compared with . techniques, but the disadvantage of also producing a higher proportion of clashing or highly inaccurate predictions. We introduce LoopWeaver, a database method that uses multidi作者: 直覺(jué)好 時(shí)間: 2025-3-29 06:43
A Robust Method for Transcript Quantification with RNA-seq Data,the abundance of transcript isoforms. Accurate abundance estimation or . of isoforms is critical for downstream differential analysis (e.g. healthy vs. diseased cells), but remains a challenging problem for several reasons. First, while various types of algorithms have been developed for abundance e作者: pulse-pressure 時(shí)間: 2025-3-29 07:54 作者: Overstate 時(shí)間: 2025-3-29 12:40
TrueSight: Self-training Algorithm for Splice Junction Detection Using RNA-seq,limited read length of NGS data, it is extremely challenging to accurately map RNA-seq reads to splice junctions, which is critically important for the analysis of alternative splicing and isoform construction. Several tools have been developed to find splice junctions by RNA-seq ., without the aid 作者: 表示向前 時(shí)間: 2025-3-29 17:49
Synthetic Sequence Design for Signal Location Search,igns employing combinatorial group testing and balanced Gray codes. Experiments in polio and adenovirus demonstrate the efficiency and generality of this procedure. In this paper, we give a new class of consecutive positive group testing designs, which offer a better tradeoff of cost, resolution, an作者: 本能 時(shí)間: 2025-3-29 22:43 作者: 闡明 時(shí)間: 2025-3-30 00:48 作者: 搖曳 時(shí)間: 2025-3-30 06:40 作者: 推崇 時(shí)間: 2025-3-30 08:51
Structure-Guided Deimmunization of Therapeutic Proteins,gs requires solving a unique set of challenges. For instance, it is increasingly apparent that mitigating potential anti-therapeutic immune responses, driven by molecular recognition of a therapeutic protein’s peptide fragments, may be best accomplished early in the drug development process. One may作者: 迎合 時(shí)間: 2025-3-30 15:15
Conference proceedings 2012, held in Barcelona, Spain, in April 2012. The 31 revised full papers presented together with 5 keynote lectures were carefully reviewed and selected from 200 submissions. The papers feature current research in all areas of computational molecular biology, including: molecular sequence analysis; rec作者: 極力證明 時(shí)間: 2025-3-30 17:09 作者: ventilate 時(shí)間: 2025-3-31 00:00 作者: 出血 時(shí)間: 2025-3-31 03:51 作者: regale 時(shí)間: 2025-3-31 08:49
,: A Ball-Based Algorithm for Structural Motifs,. . combines the best properties of previously developed methods, exploiting the composition and local geometry of a structural motif and its possible instances in order to effectively filter candidate matches. We show that on a wide range of motif matching problems, . efficiently and effectively fi作者: 無(wú)孔 時(shí)間: 2025-3-31 09:39
Evolution of Genome Organization by Duplication and Loss: An Alignment Approach,angements, we show that a direct approach based on dynamic programming leads, at best, to an efficient heuristic. We present an exact pseudo-boolean linear programming algorithm to search for the optimal alignment along with an optimal scenario of duplications and losses. Although exponential in the作者: 支形吊燈 時(shí)間: 2025-3-31 15:40 作者: 托運(yùn) 時(shí)間: 2025-3-31 21:17 作者: abracadabra 時(shí)間: 2025-4-1 01:18
Network-Based Prediction and Analysis of HIV Dependency Factors,r in AIDS progression. Our results suggest that many HDFs are yet to be discovered and that they have potential value as prognostic markers to determine pathological outcome and the likelihood of AIDS development. More generally, if multiple genome-wide gene-level studies have been performed at inde作者: 種植,培養(yǎng) 時(shí)間: 2025-4-1 03:44
Structure-Guided Deimmunization of Therapeutic Proteins,on and a T-cell epitope predictor, respectively. EpiSweep integrates structure-based protein design, sequence-based protein deimmunization, and algorithms for finding the Pareto frontier of a design space. While structure-based protein design is NP-hard, we employ integer programming techniques that作者: Acetaminophen 時(shí)間: 2025-4-1 08:48 作者: THE 時(shí)間: 2025-4-1 10:50
ansfer into the stem cell of the hematopoietic system, thus allowing the appropriate expression of the normal gene into the affected cells of hematopoietic or lymphoid lineage [33–35]. However, initial difficulties in obtaining efficient transduction of stem cells have led several investigators to a作者: Spirometry 時(shí)間: 2025-4-1 14:29 作者: 縮短 時(shí)間: 2025-4-1 21:35
