標(biāo)題: Titlebook: Razoxane and Dexrazoxane - Two Multifunctional Agents; Experimental and Cli Kurt Hellmann,Walter Rhomberg Book 2011 Springer Science+Busine [打印本頁] 作者: 法令 時(shí)間: 2025-3-21 18:04
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書目名稱Razoxane and Dexrazoxane - Two Multifunctional Agents讀者反饋學(xué)科排名
作者: Synthesize 時(shí)間: 2025-3-21 23:54
Kurt Hellmannines and modelling steps from the . methodology, which provides a bottom-up approach for engineering collaborative multi-agent societies with an emergent behaviour..The resulting MAS has self-adaptation properties, having agents that are able to change their behaviour according to changes in the env作者: 轉(zhuǎn)折點(diǎn) 時(shí)間: 2025-3-22 03:13
Kurt Hellmann,Walter RhombergSunday. Such data, he argued, would be a crucial weapon in the confessional conflict with the Protestants and also demonstrate the modern administrative standards of the church. Krose began publishing his own annual compilation of data in 1908 and set up a provisional office for church statistics in作者: 無孔 時(shí)間: 2025-3-22 07:16 作者: Magisterial 時(shí)間: 2025-3-22 10:31
Kurt Hellmann,Walter Rhombergsed precisely this point. The political system had ‘to face the fact’, Schmidtchen argued, ‘that an archaic age would come to an end, during which people believed that social insights … would emerge automatically’. Polling, already ‘a(chǎn)n informal institution in the large democratic states’, would repl作者: Grievance 時(shí)間: 2025-3-22 16:04 作者: scrape 時(shí)間: 2025-3-22 19:21 作者: slipped-disk 時(shí)間: 2025-3-23 00:06 作者: Paradox 時(shí)間: 2025-3-23 03:01
Dexrazoxane,ibit topoisomerase II..Chapter 3 is concerned essentially with dexrazoxane (ICRF-187) the dextro enantiomer of razoxane (ICRF-159). Although dexrazoxane was initially developed as an anticancer agent (like razoxane) it subsequently emerged as an interesting drug with unexpected properties. Introduct作者: 修飾語 時(shí)間: 2025-3-23 06:40
Book 2011ll analysis of their actions at the molecular level is not yet completely understood, it seems most likely that it is via an inhibition on the topoisomerase II a. Moreover, the drugs have the ability to chelate several metals including iron, copper or zinc.The protection of normal tissues is nowhere作者: 地牢 時(shí)間: 2025-3-23 10:18 作者: dermatomyositis 時(shí)間: 2025-3-23 17:39 作者: 清真寺 時(shí)間: 2025-3-23 20:02 作者: 豪華 時(shí)間: 2025-3-24 01:05
dexrazoxane are two novel drugs with some uniquely useful features. They block cell division at the G2/M border, but nowhere else, so that they have a low toxicity profile. They suppress tumor metastasis and haemorrhages through normalization of pathological blood vessels. Razoxane potentiates radi作者: 盡管 時(shí)間: 2025-3-24 02:26 作者: indoctrinate 時(shí)間: 2025-3-24 08:21
Introduction,dexrazoxane (ICRF-187) which are the subject of this book. Their history dates back to 1965 and gradually revealed a variety of modes of action which are as unexpected as they are unique – at present. The influence of razoxane and dexrazoxane on the differentiation of a pathologic neovasculature of 作者: Cloudburst 時(shí)間: 2025-3-24 13:25
Razoxane,mmarized, e.g. the block of the cell cycle in the G2/M phase, the antimetastatic and antiinvasive activity, the ability to normalize pathological tumor blood vessels, the inhibition of topoisomerase II α, and the metal chelating activity. These activites are associated with a marked radiosensitizati作者: 集聚成團(tuán) 時(shí)間: 2025-3-24 14:52
Dexrazoxane,. Dexrazoxane has two potential pharmacological activities: it is a prodrug that is hydrolyzed to an iron chelating EDTA-type structure, and it is also a strong inhibitor of topoisomerase II. The anthracycline doxorubicin is able to be reductively activated to produce damaging reactive oxygen specie作者: Headstrong 時(shí)間: 2025-3-24 20:58
Summary and Outlook,antiinvasive activity in preclinical experiments, and they are able to normalize pathological tumour blood vessels. In addition, the drugs inhibit topoisomerase II α (the full implications have yet to emerge) and they are powerful chelating agents which not only chelate iron, but also a variety of o作者: Lacunar-Stroke 時(shí)間: 2025-3-25 01:31
Introduction,s an impressive cytoprotective activity in mitigating accidental anthracycline extravasation. In retrospect, the history of the two drugs justifies random screening as a valid method for the discovery of novel and effective drugs.作者: 完全 時(shí)間: 2025-3-25 04:46
formulas can emerge in a population of autonomous agents which have no prior linguistic knowledge. We take an approach based on . such as invention, adoption and induction, and on . principles applied to a particular type of linguistic interaction known as a ...These experiments extend previous wor作者: Herd-Immunity 時(shí)間: 2025-3-25 10:39
Kurt Hellmannd dynamically changing environment..Current agent-oriented software engineering methodologies tend to focus on different levels to realise such a self-adapting behaviour, namely the agent individual level and the global system level. The first requires to design a goal-directed agent behaviour, the 作者: 手術(shù)刀 時(shí)間: 2025-3-25 15:27 作者: Postulate 時(shí)間: 2025-3-25 18:29
Kurt Hellmann,Walter Rhomberg and the global economic crisis created even in the North a need for experts and technologies to guide an increasingly complex society. As in Germany, the level of ideas was dominated by the utopia of a socially harmonious ‘national community’, which shaped both politics and the work of social exper作者: NUL 時(shí)間: 2025-3-25 21:36 作者: chandel 時(shí)間: 2025-3-26 04:13
office in the Catholic Church. Krose was strongly influenced by the ideas of the Belgian astronomer and statistician Alphonse Quetelet (1796–1874). According to Quetelet, the behaviour of individuals in a given social context displayed a certain probability to commit crime, suicide or other social 作者: APEX 時(shí)間: 2025-3-26 06:50 作者: Graphite 時(shí)間: 2025-3-26 09:46
Kurt Hellmann,Walter RhombergSelectively summarizes the >900 publications on these drugs comprehensive overview But cites most papers Shows where lacunae are作者: BRIEF 時(shí)間: 2025-3-26 14:18
978-94-017-8048-3Springer Science+Business Media B.V. 2011作者: negligence 時(shí)間: 2025-3-26 18:39
EHD Equipment and Applications,07), and South China Sea (Han et al. 2008; Lu 2007). It has been estimated that there are about 1,000 ～24,000 Gt of carbon in global methane hydrate zones (Dickens et al. 1997; Harvey and Huang 1995; Kvenvolden 1988; MacDonald 1990; Makogon and Makogon 1997). Methane hydrates have the potential to b作者: Charitable 時(shí)間: 2025-3-27 00:14
Internals . . . . . . . . . . . . . . . . . . . . 8 1. 6 Detecting Core Flow Anomalies . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . 10 1. 7 CANDU Reactor Applications . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 10 1. 8 In-Situ Response-Time Testing of Temperature S作者: GRE 時(shí)間: 2025-3-27 03:04 作者: Pelago 時(shí)間: 2025-3-27 08:13 作者: 陶瓷 時(shí)間: 2025-3-27 09:40
l as non-uniform current distribution that depend on the geometry, frequency, and scan angle. This complicated parameter dependence results from mutual coupling effects observable among all elements in the array. It is usually difficult to explain and formulate the mutual coupling phenomenon, which 作者: 流浪 時(shí)間: 2025-3-27 16:44
The Invisible Weather Team,Anyone looking for a harmonious blend of shared public and private responsibilities in the United States need look no further than broadcast meteorology. It’s a realm where one federal agency, hundreds of TV stations, and an array of other private entities collaborate to bring information to the public.作者: hypnotic 時(shí)間: 2025-3-27 18:05
