標(biāo)題: Titlebook: Quantum Mechanics in Drug Discovery; Alexander Heifetz Book 2020 Springer Science+Business Media, LLC, part of Springer Nature 2020 QM app [打印本頁(yè)] 作者: CILIA 時(shí)間: 2025-3-21 20:02
書目名稱Quantum Mechanics in Drug Discovery影響因子(影響力)
書目名稱Quantum Mechanics in Drug Discovery影響因子(影響力)學(xué)科排名
書目名稱Quantum Mechanics in Drug Discovery網(wǎng)絡(luò)公開度
書目名稱Quantum Mechanics in Drug Discovery網(wǎng)絡(luò)公開度學(xué)科排名
書目名稱Quantum Mechanics in Drug Discovery被引頻次
書目名稱Quantum Mechanics in Drug Discovery被引頻次學(xué)科排名
書目名稱Quantum Mechanics in Drug Discovery年度引用
書目名稱Quantum Mechanics in Drug Discovery年度引用學(xué)科排名
書目名稱Quantum Mechanics in Drug Discovery讀者反饋
書目名稱Quantum Mechanics in Drug Discovery讀者反饋學(xué)科排名
作者: 小教堂 時(shí)間: 2025-3-21 23:23
Quantum Mechanics in Drug Discovery978-1-0716-0282-9Series ISSN 1064-3745 Series E-ISSN 1940-6029 作者: Prostatism 時(shí)間: 2025-3-22 01:59 作者: coltish 時(shí)間: 2025-3-22 05:31
Geometry Optimization, Transition State Search, and Reaction Path Mapping Accomplished with the FraRecent development of the fragment molecular orbital (FMO) method related to energy gradients, geometry optimization, transition state search, and chemical reaction mapping is summarized. The frozen domain formulation of FMO is introduced in detail, and the structure of related GAMESS input files for FMO is described.作者: explicit 時(shí)間: 2025-3-22 10:08 作者: Insatiable 時(shí)間: 2025-3-22 16:33
Methods in Molecular Biologyhttp://image.papertrans.cn/q/image/781336.jpg作者: 憤怒歷史 時(shí)間: 2025-3-22 20:38 作者: BRIEF 時(shí)間: 2025-3-22 23:44 作者: Astigmatism 時(shí)間: 2025-3-23 04:20 作者: 楓樹 時(shí)間: 2025-3-23 08:34
Jinfeng Liu,Xiao Heo bypass the blood–brain barrier to reach the central nervous system. The presented chapter highlights the method of intranasal delivery in mice using chitosan–siRNA nanoparticle formulation, under mild anesthesia and the identification of successful siRNA delivery in the brain tissues, through hist作者: certitude 時(shí)間: 2025-3-23 10:03
Alexander Heifetz,Tim James,Michelle Southey,Mike J. Bodkin,Steven Bromidgeng cancer and normal cells. The protocol provided is geared to provide the readers an overview of developing multifunctional dendrimer-based nanoparticles. However, based on the individual’s objective and the type of combinatorial drugs to deliver, the protocol may need modifications in achieving ma作者: electrolyte 時(shí)間: 2025-3-23 15:38
Dmitri G. FedorovPDAC, which demonstrated a median survival increase from 8.9?months to 17.6?months in ten subjects augmented with sonoporation compared to 63 historical controls (.?=?0.011). Recent efforts to optimize this platform and move forward to a larger Phase II clinical trial will be described.作者: Valves 時(shí)間: 2025-3-23 18:48
Andrew Anighorong cancer and normal cells. The protocol provided is geared to provide the readers an overview of developing multifunctional dendrimer-based nanoparticles. However, based on the individual’s objective and the type of combinatorial drugs to deliver, the protocol may need modifications in achieving ma作者: wall-stress 時(shí)間: 2025-3-23 22:35 作者: Angiogenesis 時(shí)間: 2025-3-24 05:57 作者: 急急忙忙 時(shí)間: 2025-3-24 08:37 作者: Hyperalgesia 時(shí)間: 2025-3-24 11:09 作者: BOON 時(shí)間: 2025-3-24 15:11
Alexander Heifetz,Andrea Townsend-Nicholsonpanies that are developing drug delivery technologies. Kewal K. Jain, MD v Contents Preface. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . v Contributors. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .作者: 加花粗鄙人 時(shí)間: 2025-3-24 21:40 作者: 蘑菇 時(shí)間: 2025-3-25 02:46
Matthew Habgood,Tim James,Alexander Heifetzpanies that are developing drug delivery technologies. Kewal K. Jain, MD v Contents Preface. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . v Contributors. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .作者: emission 時(shí)間: 2025-3-25 03:29
Alfonso Pozzanpanies that are developing drug delivery technologies. Kewal K. Jain, MD v Contents Preface. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . v Contributors. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .作者: RAG 時(shí)間: 2025-3-25 07:47
Alessio Lodola,Donatella Callegari,Laura Scalvini,Silvia Rivara,Marco Morby conditions such as pH, temperature, degradation, drug diffusion and binding interactions. Having prolonged, controlled and targeted releases of bioactive can minimise the number of drug concentrations and injection frequencies at the affected area. This section highlights the drug delivery system作者: aptitude 時(shí)間: 2025-3-25 14:44
Book 2020 reproducible modeling protocols, and tips on troubleshooting and avoiding known pitfalls.?.Cutting-edge and?unique,?.Quantum Mechanics in Drug Discovery. .is a valuable resourcefor structural and molecular biologists, computational and medicinal chemists, pharmacologists, and drug designers..作者: CAB 時(shí)間: 2025-3-25 17:01 作者: 破譯密碼 時(shí)間: 2025-3-25 20:59 作者: 河潭 時(shí)間: 2025-3-26 02:22 作者: FLINT 時(shí)間: 2025-3-26 05:19 作者: 擦試不掉 時(shí)間: 2025-3-26 10:08 作者: miniature 時(shí)間: 2025-3-26 16:15
1064-3745 y. .is a valuable resourcefor structural and molecular biologists, computational and medicinal chemists, pharmacologists, and drug designers..978-1-0716-0284-3978-1-0716-0282-9Series ISSN 1064-3745 Series E-ISSN 1940-6029 作者: CRACK 時(shí)間: 2025-3-26 19:09 作者: 兇猛 時(shí)間: 2025-3-27 00:21 作者: 昏睡中 時(shí)間: 2025-3-27 01:34 作者: 浪蕩子 時(shí)間: 2025-3-27 06:36
Analyzing GPCR-Ligand Interactions with the Fragment Molecular Orbital (FMO) Method,ard to detect. Integration of GPCR crystallography or homology modelling with FMO reveals atomistic details of the individual contributions of each residue and water molecule toward ligand binding, including an analysis of their chemical nature. Such information is essential for an efficient structu作者: expeditious 時(shí)間: 2025-3-27 13:17 作者: 類似思想 時(shí)間: 2025-3-27 16:52 作者: 值得尊敬 時(shí)間: 2025-3-27 19:50 作者: BRAVE 時(shí)間: 2025-3-28 00:03
Binding Free Energy Calculation Using Quantum Mechanics Aimed for Drug Lead Optimization,lds, such as electronic polarization, metal coordination, and covalent binding; moreover, quantum mechanical approaches are systematically improvable. By treating all elements and interactions on equal footing, and avoiding the need of system-dependent parameterizations, they provide a greater degre作者: textile 時(shí)間: 2025-3-28 04:01
Molecular Docking Using Quantum Mechanical-Based Methods,ular systems has gained substantial attention in the last decade. A quantum mechanical description of the interactions involved in molecular association of biomolecules may lead to better accuracy compared to molecular mechanics, since there are many physical phenomena that cannot be correctly descr作者: 許可 時(shí)間: 2025-3-28 07:34
Design and SAR Analysis of Covalent Inhibitors Driven by Hybrid QM/MM Simulations,ceptor (EGFR). In this context, QM/MM simulations gave valuable information in terms of geometry (i.e., of transition states and metastable intermediates) and reaction energetics that allowed to correctly predict inhibitor binding orientation and substituent effect on enzyme inhibition. What is more作者: vanquish 時(shí)間: 2025-3-28 13:34 作者: Musket 時(shí)間: 2025-3-28 15:01
Christofer S. Tautermannme. There is currently no cure available for any neurodegenerative disease, and the existing therapeutic interventions only alleviate the symptoms of the disease. The advances in the drug discovery research have come to a halt with a lack of effective means to deliver drugs at the targeted site. In 作者: 腐敗 時(shí)間: 2025-3-28 20:56 作者: Magnificent 時(shí)間: 2025-3-29 01:10
Alexander Heifetz,Tim James,Michelle Southey,Mike J. Bodkin,Steven Bromidgee side effects. Dendrimer-based nanoparticles have received considerable attention for multifunctional therapeutic delivery. In this chapter, we describe the methods for encapsulating the chemotherapeutic drug, cisplatin (CDDP), and human antigen R (HuR)-targeted siRNA into dendrimer nanoparticles f作者: 王得到 時(shí)間: 2025-3-29 03:50 作者: Pulmonary-Veins 時(shí)間: 2025-3-29 08:38
Andrew Anighoroe side effects. Dendrimer-based nanoparticles have received considerable attention for multifunctional therapeutic delivery. In this chapter, we describe the methods for encapsulating the chemotherapeutic drug, cisplatin (CDDP), and human antigen R (HuR)-targeted siRNA into dendrimer nanoparticles f作者: 內(nèi)向者 時(shí)間: 2025-3-29 12:05 作者: ADAGE 時(shí)間: 2025-3-29 18:59 作者: 滔滔不絕的人 時(shí)間: 2025-3-29 21:04
Dmitri G. Fedorov,Hui Li,Vladimir Mironov,Yuri Alexeev to describe all the technologies. The aim of this book is to put together descriptions of important selective technologies used in DDS. Important drugs, new technologies such as nanoparticles, as well as important therapeutic applications, are taken into consideration in this selection. This book w作者: Mortal 時(shí)間: 2025-3-30 03:04
Inaki Morao,Alexander Heifetz,Dmitri G. Fedorov to describe all the technologies. The aim of this book is to put together descriptions of important selective technologies used in DDS. Important drugs, new technologies such as nanoparticles, as well as important therapeutic applications, are taken into consideration in this selection. This book w作者: Focus-Words 時(shí)間: 2025-3-30 07:25 作者: 沐浴 時(shí)間: 2025-3-30 12:14 作者: 看法等 時(shí)間: 2025-3-30 14:38 作者: 殺菌劑 時(shí)間: 2025-3-30 18:54 作者: 中國(guó)紀(jì)念碑 時(shí)間: 2025-3-31 00:23 作者: curriculum 時(shí)間: 2025-3-31 01:08 作者: Vulvodynia 時(shí)間: 2025-3-31 08:50
Claudio N. Cavasottoan important component of drug development and therapeutics. The field is quite extensive and requires an encyclopedia to describe all the technologies. The aim of this book is to put together descriptions of important selective technologies used in DDS. Important drugs, new technologies such as nan作者: Chronological 時(shí)間: 2025-3-31 10:55
M. Gabriela Aucar,Claudio N. Cavasottoan important component of drug development and therapeutics. The field is quite extensive and requires an encyclopedia to describe all the technologies. The aim of this book is to put together descriptions of important selective technologies used in DDS. Important drugs, new technologies such as nan作者: 袖章 時(shí)間: 2025-3-31 14:35 作者: 使成整體 時(shí)間: 2025-3-31 18:41 作者: Flagging 時(shí)間: 2025-4-1 01:21 作者: 內(nèi)行 時(shí)間: 2025-4-1 04:59
QM Implementation in Drug Design: Does It Really Help?,ool in drug discovery in both academic research and pharmaceutical industry. Molecular mechanics (MM)-based approaches are widely utilized to assist the discovery of new drug candidates. However, the complexity of protein–ligand interactions challenges the accuracy and efficiency of the commonly use作者: BILL 時(shí)間: 2025-4-1 06:40 作者: 招待 時(shí)間: 2025-4-1 11:01 作者: 不透氣 時(shí)間: 2025-4-1 15:54
Taking Water into Account with the Fragment Molecular Orbital Method,lecular interactions of biomolecular systems .. The orbital energies and the inter-fragment interaction energies (IFIEs) for a specific molecular structure can be obtained directly by performing FMO calculations by exposing water molecules and counterions around biomolecular systems. Then, it is nec作者: inhumane 時(shí)間: 2025-4-1 20:37
Computational Methods for Biochemical Simulations Implemented in GAMESS,lecular mechanics (QM/MM), semi-empirical, and fragmentation approaches. A detailed summary of capabilities is provided for the QM/MM implementation in QuanPol program and the fragment molecular orbital (FMO) method. Molecular modeling and visualization packages useful for biochemical simulations wi作者: 碎片 時(shí)間: 2025-4-1 23:56
Accurate Scoring in Seconds with the Fragment Molecular Orbital and Density-Functional Tight-Bindina promising means by which to achieve this, traditional QM is not applicable for large biological systems due to its high computational cost. Here, the fragment molecular orbital (FMO) method has been combined with the density-functional tight-binding (DFTB) method to compute energy calculations of 作者: TSH582 時(shí)間: 2025-4-2 03:17
Protein Molecular Dynamics Simulations with Approximate QM: What Can We Learn?,e of isolated proteins. However, while protein-protein interactions are ubiquitous in nature, they are not considered in parameterization efforts and are far less understood than isolated proteins. A better characterization of intermolecular interactions is widely recognized as a key to revolutioniz
